Evidence for nonreciprocal organization of the mouse auditory thalamocortical-corticothalamic projection systems

The Journal of Comparative Neurology
D A Llano, S M Sherman

Abstract

We tested the hypothesis that information is routed from one area of the auditory cortex (AC) to another via the dorsal division of the medial geniculate body (MGBd) by analyzing the degree of reciprocal connectivity between the auditory thalamus and cortex. Biotinylated dextran amine injected into the primary AC (AI) or anterior auditory field (AAF) of mice produced large, "driver-type" terminals primarily in the MGBd, with essentially no such terminals in the ventral MGB (MGBv). In contrast, small, "modulator-type" terminals were found primarily in the MGBv, and this coincided with areas of retrogradely labeled thalamocortical cell bodies. After MGBv injections, anterograde label was observed in layers 4 and 6 of the AI and AAF, which coincided with retrogradely labeled layer 6 cell bodies. After MGBd injections, thalamocortical terminals were seen in layers 1, 4, and 6 of the secondary AC and dorsoposterior AC, which coincided with labeled layer 6 cell bodies. Notably, after MGBd injection, a substantial number of layer 5 cells were labeled in all AC areas, whereas very few were seen after MGBv injection. Further, the degree of anterograde label in layer 4 of cortical columns containing labeled layer 6 cell bodies was greate...Continue Reading

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Citations

Feb 25, 2014·Neurophysiology·Charles C Lee, Kazuo Imaizumi
Dec 8, 2009·Nature Neuroscience·Brian B TheyelS Murray Sherman
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Charles C Lee, S Murray Sherman
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Angela N ViaeneS Murray Sherman
Jul 11, 2012·Neuroreport·Charles C LeeS Murray Sherman
Nov 5, 2010·Journal of Neurophysiology·Angela N ViaeneS Murray Sherman
Nov 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel A LlanoDonald M Caspary
Apr 4, 2014·Nature·Seung Wook OhHongkui Zeng
Dec 18, 2013·Brain Topography·Flora M Antunes, Manuel S Malmierca
Jun 10, 2014·Hearing Research·Kevin A StebbingsDaniel A Llano
Nov 20, 2015·Frontiers in Neural Circuits·Charles C Lee
Mar 19, 2014·The Journal of Comparative Neurology·Makoto TakemotoWen-Jie Song
May 26, 2011·Neuroscience and Biobehavioral Reviews·Guangying K WuLi I Zhang
Jun 5, 2015·Frontiers in Computational Neuroscience·Nelson Cortes, Carl van Vreeswijk
Jun 26, 2012·Brain and Language·Charles C Lee
Jan 3, 2015·Brain and Language·Anastasia A BohsaliBruce Crosson
Jun 5, 2016·Hearing Research·Alexandria M H Lesicko, Daniel A Llano
Aug 27, 2016·Frontiers in Neuroanatomy·Emmanuel Márquez-LegorretaEnrique Saldaña
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Sep 12, 2017·ELife·Sebastian A Vasquez-LopezJohannes C Dahmen
Feb 2, 2010·Nature Neuroscience·Gideon RothschildAdi Mizrahi
Oct 11, 2013·Journal of Neurophysiology·Daniel A LlanoKevin A Stebbings

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