PMID: 3747519Aug 1, 1986Paper

Evidence for nuclear processing of progesterone receptors in rat placenta

Journal of Steroid Biochemistry
T F Ogle

Abstract

The distribution of the progesterone receptor (Rp) in cytosolic and nuclear compartments of placenta has been studied in intact and ovariectomized (Ovx) rats on the 14th day of pregnancy. Removal of estradiol (E) and progesterone (P) by Ovx caused a 50% decrease in progesterone receptors from cytosolic and nuclear compartments. Estradiol replacement restored binding to intact levels. Progesterone, given 19 h after E, induced an additional 3-fold increment in the number of cytosolic and nuclear binding sites 1 h later. Four hours after progesterone the number of receptor sites in the placenta fell 60%, signifying processing. This was followed 4 h later by reversal of processing mechanisms leading to full recovery of nuclear and cytoplasmic binding sites. Actinomycin D (0.6 mg/ani) was found to have no influence on these events. On the other hand cycloheximide (0.5 mg/ani) completely prevented processing of binding sites when administered at the same time as progesterone or 2 h before, but did not influence the unmasking of nuclear sites which occurred 1 h after a progesterone challenge. The cycloheximide block to processing was partial when given 2 or 3 h after progesterone (61 and 43% complete, respectively). The full complemen...Continue Reading

References

Aug 1, 1975·FEBS Letters·B T Hill, S Whatley
Jan 1, 1979·Methods in Enzymology·W W Cleland
Jul 1, 1977·The Journal of Endocrinology·T F Ogle, J I Kitay
Mar 14, 1978·Biochimica Et Biophysica Acta·A Cornish-Bowden, R Eisenthal
Mar 1, 1978·Biology of Reproduction·J A Cidlowski, T G Muldoon
Nov 1, 1978·Endocrinology·M R Walters, J H Clark
May 1, 1986·Journal of Steroid Biochemistry·T F Ogle
Jun 1, 1974·The Biochemical Journal·R Eisenthal, A Cornish-Bowden
Feb 23, 1984·Nature·W V WelshonsJ Gorski
Jan 1, 1983·Molecular and Cellular Biochemistry·J A Kassis, J Gorski
Feb 1, 1982·Journal of Steroid Biochemistry·T F Ogle, B K Beyer

❮ Previous
Next ❯

Citations

Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·Y ZhouT F Ogle
Apr 26, 2012·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Joanna M BiazikMichael B Thompson
Mar 1, 1997·American Journal of Obstetrics and Gynecology·G J HaluskaM J Novy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.