PMID: 2487079Jan 1, 1989Paper

Evidence for only depolarizing rod bipolar cells in the primate retina

Visual Neuroscience
R P Dolan, P H Schiller

Abstract

The mammalian rod bipolar, for which only one class has been identified, has been described as being hyperpolarizing by some investigators and depolarizing by others. We now report the effects of 2-amino-4-phosphonobutyrate (APB), a potent blocker of depolarizing bipolar cells, on visual behavior in the dark-adapted monkey. While in mesopic and photopic conditions only the monkeys' ability to detect incremental stimuli is impaired, under scotopic conditions all light mediated response in the monkey is eliminated. Assuming APB is acting on rod bipolars in the same fashion as it does on cone bipolars, we conclude that the primate rod bipolars all depolarize to light and that the ON and OFF channels are formed by the amacrine cell network.

References

Mar 22, 1985·The Journal of Comparative Neurology·R G Pourcho, D J Goebel
Jan 1, 1986·Vision Research·P H Schiller
Jun 1, 1988·Journal of Neurophysiology·F MüllerT Voigt
Aug 3, 1986·Nature·P H SchillerJ H Maunsell
Oct 4, 1974·Science·H Kolb, E V Famiglietti
Mar 1, 1973·The Journal of Comparative Neurology·B B Boycott, H Kolb
May 1, 1982·Journal of Neurophysiology·R Nelson
Jan 1, 1983·Vision Research·H Kolb, R Nelson
Jan 1, 1981·Vision Research·E V Famiglietti
Jan 1, 1953·Journal of Neurophysiology·S W KUFFLER

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Citations

Jan 1, 1994·Vision Research·P J Demarco, M K Powers
Nov 19, 1997·Progress in Neurobiology·R R Poznanski, O Umino
Apr 12, 2000·Progress in Neurobiology·H Nakagawa, N Matsumoto
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter H Schiller
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P J DeMarcoM K Powers
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·S H DeVries, D A Baylor
Apr 1, 1996·The Journal of General Physiology·R L Chappell, F J Rosenstein
Sep 1, 1993·Journal of Neurocytology·B B Boycott, J M Hopkins
May 2, 2000·The Journal of Physiology·A Berntson, W R Taylor
Jan 15, 2008·Survey of Ophthalmology·Isabelle AudoAnthony T Moore
May 1, 1997·Visual Neuroscience·S A BloomfieldT Osborne
May 1, 1993·Visual Neuroscience·W J Brunken, X T Jin
Feb 16, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Allison L DorfmanPierre Lachapelle
Jun 13, 2018·Vision·Omar HassanStephen T Hammett
Sep 1, 1994·The Journal of Comparative Neurology·E StrettoiE Raviola
Nov 8, 1992·The Journal of Comparative Neurology·E StrettoiR F Dacheux

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