PMID: 6163004Jan 15, 1981Paper

Evidence for participation of kinins in the antihypertensive effect of converting enzyme inhibition

Klinische Wochenschrift
A OverlackF Krück

Abstract

In low- and normal- renin hypertensive patients, but not in high-renin patients, the acute antihypertensive response to the angiotensin-converting enzyme (ACE) inhibitor captopril was completely blocked by aprotinin-induced kallikrein inhibition. Blood pressure reduction with long-term ACE inhibition could be overcome only in part by aprotinin. It is proposed that in low- and normal-renin hypertension the vasodepressor effect of acute ACE inhibition is mainly due to kinin accumulation. Conversely, in high-renin patients a fall in angiotensin II concentration accounts for the hypotensive response to captopril. From the pressor effect of aprotinin in chronically captopril treated patients it appears that kinins are also involved in the blood pressure reduction with long-term ACE inhibition. The finding that ACE inhibition and kallikrein blockade produced predictable and opposite effects on blood pressure suggests broad participation of changes in depressor kinin production in the control of vascular tone in essential hypertension.

References

Oct 1, 1979·Clinical Science·F H DerkxM A Schalekamp
Dec 1, 1979·Clinical Science·T C LeeM H Maxwell
Jul 28, 1977·The New England Journal of Medicine·G H Williams, N K Hollenberg
May 4, 1978·The New England Journal of Medicine·H GavrasD N McKinstry
Nov 1, 1978·Clinical Science and Molecular Medicine·R J CodyF M Fouad
Nov 1, 1979·The Journal of Clinical Endocrinology and Metabolism·F H DerkxM A Schalekamp
Jul 1, 1971·Biochemical Pharmacology·D W Cushman, H S Cheung
Nov 1, 1973·Prostaglandins·T Tuvemo, L Wide
Jun 1, 1980·The Journal of Clinical Investigation·S L SwartzT J Moore

❮ Previous
Next ❯

Citations

Jan 1, 1986·Clinical and Experimental Hypertension. Part A, Theory and Practice·K ChimoriK Miura
Apr 21, 1982·The American Journal of Cardiology·A KonradsA Helber
Feb 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·D Royston

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.