Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and delivery.

American Journal of Obstetrics and Gynecology
Shaun P MurphySurendra Sharma

Abstract

The purpose of this study was to determine in a mouse model whether uterine natural killer (uNK) cell cytotoxic activation induces infection/inflammation-associated preterm labor and delivery. Wild type or interleukin (IL)-10(-/-) mice were injected intraperitoneally with lipopolysaccharide on gestational day 14. Mice were either killed for collection of uteroplacental tissue, spleen, and serum or allowed to deliver. Uteroplacental tissue was used for histology and characterization of uNK cells. Low-dose lipopolysaccharide treatment triggered preterm labor and delivery in IL-10(-/-), but not wild type mice, in a manner independent of progesterone levels. Preterm labor and delivery in IL-10(-/-) mice was associated with an increased number and placental infiltration of cytotoxic uNK cells and placental cell death. Depletion of NK cells or tumor necrosis factor (TNF)-alpha neutralization in these mice restored term delivery. Furthermore, TNF-alpha neutralization prevented uNK cell infiltration and placental cell apoptosis. The uNK cell-TNF-alpha-IL-10 axis plays an important role in the genesis of infection/inflammation-induced preterm labor/delivery.

Associated Clinical Trials

References

May 1, 1992·American Journal of Obstetrics and Gynecology·R RomeroJ Williams
May 1, 1990·The Journal of Clinical Investigation·R RomeroP B Sehgal
Jan 10, 1985·The New England Journal of Medicine·M C McCormick
Nov 25, 1993·The New England Journal of Medicine·M Hack, A A Fanaroff
Mar 5, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M MazorA Bashiri
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S KimW M Yokoyama
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
Jul 2, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·John R G ChallisJohn P Newnham
Jul 27, 2002·American Journal of Perinatology·W W AndrewsR L Goldenberg
Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
Oct 29, 2002·Seminars in Neonatology : SN·Roberto RomeroKarim Kalache
Sep 13, 2003·Journal of the Society for Gynecologic Investigation·S M YellonM A Kirby
Feb 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Felipe Vadillo-Ortega, Guadalupe Estrada-Gutiérrez
Apr 28, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Uma SinghAndrés López Bernal
Oct 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hernan D KopcowJack L Strominger
Dec 21, 2005·American Journal of Reproductive Immunology : AJRI·Nazeeh HannaSurendra Sharma
Feb 18, 2006·Nature Reviews. Genetics·Haibin Wang, Sudhansu K Dey
May 2, 2006·American Journal of Obstetrics and Gynecology·Emmet HirschMala Mahendroo

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Citations

Sep 10, 2010·Infectious Diseases in Obstetrics and Gynecology·Jessica E ThaxtonSurendra Sharma
Jan 27, 2011·Journal of Perinatal Medicine·Byoung Jae KimBo Hyun Yoon
Jan 10, 2013·Annual Review of Immunology·Adrian Erlebacher
Aug 29, 2013·American Journal of Epidemiology·Quaker E HarmonChristy L Avery
Oct 20, 2015·American Journal of Obstetrics and Gynecology·Yana FilipovichEmmet Hirsch
Jan 20, 2016·Seminars in Immunopathology·David A Clark
Dec 22, 2015·Biochemical and Biophysical Research Communications·Xiaomin KangAimin Zhao
Feb 22, 2011·Journal of Reproductive Immunology·Satyan KalkunteSurendra Sharma
Feb 8, 2011·Placenta·W NorrisS Kalkunte
Mar 20, 2010·Journal of Reproductive Immunology·Surendra SharmaSatyan Kalkunte
Nov 6, 2009·Journal of Reproductive Immunology·Yi LinShigeru Saito
Oct 20, 2009·Journal of Reproductive Immunology·Satyan KalkunteSurendra Sharma
Jul 29, 2015·American Journal of Obstetrics and Gynecology·Yana FilipovichEmmet Hirsch
Mar 2, 2013·American Journal of Reproductive Immunology : AJRI·Elizabeth A Bonney
Aug 18, 2010·American Journal of Reproductive Immunology : AJRI·Ingrid CardenasRobert E Means
Feb 19, 2010·American Journal of Reproductive Immunology : AJRI·Jessica E Thaxton, Surendra Sharma
Jul 6, 2014·American Journal of Reproductive Immunology : AJRI·Karen RacicotGil Mor
Oct 3, 2015·American Journal of Obstetrics and Gynecology·Gil Mor, Ja-Young Kwon
Oct 2, 2014·American Journal of Reproductive Immunology : AJRI·Shi-Bin Cheng, Surendra Sharma
Oct 22, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Verónica Zaga-ClavellinaAngel Chávez-Mendoza
Jul 20, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zeynep Alpay SavasanSonia S Hassan
May 19, 2011·International Immunopharmacology·Ziyan YangXia Zhang
Sep 7, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mostafa Fouad GomaaNahla Mohammad Aawd
Jul 3, 2015·Reproductive Sciences·Mark Phillippe
Jan 10, 2018·Biology of Reproduction·Svetlana DambaevaKenneth D Beaman
Mar 24, 2018·Immunology and Cell Biology·Barbara CastellanaAlexander G Beristain
Jun 25, 2016·Seminars in Immunopathology·Shi-Bin Cheng, Surendra Sharma
Nov 5, 2016·The Journal of Endocrinology·S P SivarajasingamM R Johnson
Dec 27, 2018·American Journal of Reproductive Immunology : AJRI·Maureen L KimNazeeh Hanna
Apr 11, 2017·Biology of Reproduction·Stephen J RenaudMichael J Soares
Jul 8, 2011·American Journal of Reproductive Immunology : AJRI·Tania NeversSurendra Sharma
Sep 8, 2011·Expert Review of Clinical Immunology·Sara F RinaldiJane E Norman
Feb 11, 2019·Scandinavian Journal of Immunology·Hui-Qing Lu, Rong Hu

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