PMID: 2502792Jan 1, 1989Paper

Evidence for perceptual masking of the discriminative morphine stimulus

Psychopharmacology
D V Gauvin, A M Young

Abstract

Morphine-amphetamine and morphine-naltrexone interactions were examined in three groups of White Carneaux pigeons (n = 3), which were trained in a two-choice drug discrimination procedure under a FR-30 schedule of food reinforcement using 3.2 mg/kg morphine and saline as discriminative stimuli. Once stimulus control was acquired by these initial training stimuli, the training doses of morphine were gradually changed to 1.0 mg/kg for group A and to 10 mg/kg for group C. The three groups differed in the minimum dose required for stimulus control and the drugs to which the training stimulus generalized. Stimulus generalization to amphetamine was inversely related to training dose. Amphetamine potentiated the discriminative stimulus properties of morphine. Naltrexone blocked the discriminative stimulus properties of morphine to varying degrees, which appeared to be limited by the training dose and the rate-suppressing effects of naltrexone when administered alone. Challenging the morphine stimulus with amphetamine resulted in a qualitatively similar blockade. This blockade was a direct function of the morphine training dose. It is argued that MS-AMP interactions result in perceptual masking of the MS stimulus, which can be differen...Continue Reading

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Citations

Jan 1, 1996·Psychopharmacology·J A White, I P Stolerman
Mar 1, 2012·Psychopharmacology·David R SchulzeLance R McMahon
Dec 27, 1995·European Journal of Pharmacology·D V GauvinF A Holloway
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S Pournaghash, A L Riley
Jan 1, 1994·Pharmacology, Biochemistry, and Behavior·D V GauvinF A Holloway
Jan 1, 1995·Pharmacology, Biochemistry, and Behavior·A TomieL L Peoples
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·M GaiardiM Babbini
Mar 25, 1998·Pharmacology, Biochemistry, and Behavior·M Filip, E Przegaliński
Jun 19, 1998·Pharmacology, Biochemistry, and Behavior·X LamasN K Mello
Nov 17, 2001·Behavioural Pharmacology·M GaiardiM Bartoletti
Dec 8, 2009·The Journal of Pharmacology and Experimental Therapeutics·Donna M PlattRoger D Spealman
Mar 23, 2012·The Journal of Pharmacology and Experimental Therapeutics·Colin S CunninghamLance R McMahon
Jul 21, 2012·The Journal of Pharmacology and Experimental Therapeutics·Cindy Achat-MendesRoger D Spealman
Aug 3, 2011·Behavioural Pharmacology·Ian P StolermanKathleen A Grant
Dec 5, 2008·Drug and Alcohol Dependence·W L Woolverton, Zhixia Wang
May 2, 2006·European Journal of Pharmacology·Lawrence P CarterCharles P France
Apr 21, 2005·European Journal of Pharmacology·Agnieszka KorkoszPrzemyslaw Bienkowski
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May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Stacy L Sell, Charles P France

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