Evidence for proteins involved in prophenoloxidase cascade Eisenia fetida earthworms.

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Petra ProcházkováMartin Bilej

Abstract

The prophenoloxidase cascade represents one of the most important defense mechanisms in many invertebrates. Following the recognition of microbial saccharides by pattern recognition molecules, proteinases cleave inactive prophenoloxidase to its active form, phenoloxidase. Phenoloxidase is a key enzyme responsible for the catalysis of the melanization reaction. Final product melanin is involved in wound healing and immune responses. Prophenoloxidase cascade has been widely described in arthropods; data in other invertebrate groups are less frequent. Here we show detectable phenoloxidase activity in 90-kDa fraction of the coelomic fluid of earthworms Eisenia fetida. Amino acid sequencing of peptides from the active fraction revealed a partial homology with invertebrate phenoloxidases and hemocyanins. Moreover, the level of phenoloxidase activity is lower and the activation slower as compared to other invertebrates.

References

Jan 1, 1991·Developmental and Comparative Immunology·V J Smith, K Söderhäll
Jan 1, 1981·Developmental and Comparative Immunology·E Stein, E L Cooper
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·A C DaquinagT Tsukamoto
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·A AspánK Söderhäll
Feb 22, 1995·Biochimica Et Biophysica Acta·A Sánchez-FerrerF García-Carmona
Apr 15, 1994·Annals of the New York Academy of Sciences·K SöderhällM W Johansson
Apr 22, 1996·FEBS Letters·T ZlatevaM Beltramini
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z LiangK Söderhäll
Apr 2, 1998·Current Opinion in Immunology·K Söderhäll, L Cerenius
Sep 25, 1998·The Journal of Biological Chemistry·H Decker, T Rimke
Jul 30, 1999·Developmental and Comparative Immunology·P B Armstrong, J P Quigley
Jul 6, 2000·The Journal of Biological Chemistry·T Nagai, S Kawabata
Jul 19, 2000·Insect Biochemistry and Molecular Biology·M R ChaseM Sugumaran
Nov 1, 2002·Developmental Cell·Ennio De GregorioPaul T Brey
Dec 6, 2002·The Biochemical Journal·Elmar Jaenicke, Heinz Decker
Mar 27, 2004·Developmental and Comparative Immunology·Heinz Decker, Elmar Jaenicke
May 18, 2004·Journal of Invertebrate Pathology·Stuart G FieldNico K Michiels
Jun 18, 2004·Immunological Reviews·Lage Cerenius, Kenneth Söderhäll
Aug 25, 2004·Biochemical and Biophysical Research Communications·So Young LeeKenneth Söderhäll
Dec 24, 2004·The EMBO Journal·Yong ZhuJeak Ling Ding
Jul 26, 2005·Immunogenetics·Larry J DishawCharles H Bigger
Dec 22, 2005·Immunology Letters·E L CooperP Nemeth

❮ Previous
Next ❯

Citations

Sep 18, 2013·Ecotoxicology and Environmental Safety·Yuya HayashiJaneck J Scott-Fordsmand
Sep 4, 2013·Journal of Invertebrate Pathology·Petra ProcházkováMartin Bilej
Aug 17, 2012·Proceedings. Biological Sciences·C V Palmer, N Traylor-Knowles
Dec 14, 2011·Cellular and Molecular Life Sciences : CMLS·Céline Boidin-WichlaczAurélie Tasiemski
Feb 29, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·J HomaE Kolaczkowska
Sep 10, 2019·Developmental and Comparative Immunology·P ProchazkovaM Bilej

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.