PMID: 6988204Jan 1, 1980Paper

Evidence for proteolysis during purification of relaxin from pregnant sow ovaries

Endocrine Research Communications
S C KwokH D Niall

Abstract

The proteolytic degradation of relaxin during its isolation from pregnant sow ovaries has been examined. Ovaries from pregnant sows were selected and divided into three groups according to the stages of pregnancy. Each group was extracted with and without protease inhibitors. It was found that protease(s) were present in all groups of ovaries and that a 2-4 fold increase in yield of total relaxin was obtained when isolation and purification was carried out in the presence of protease inhibitors. However the ratio of the three forms of relaxin remain unchanged.

References

Feb 1, 1978·Biology of Reproduction·J Z KendallG D Bryant-Greenwood
Mar 21, 1977·Biochemical and Biophysical Research Communications·C Schwabe, J K McDonald
Aug 26, 1977·Science·C Schwabe, J K McDonald
May 17, 1976·Biochemical and Biophysical Research Communications·C SchwabeB G Steinetz
Mar 1, 1974·Biology of Reproduction·L L Espey
Jan 1, 1974·Archives of Biochemistry and Biophysics·C D Sherwood, E M O'Byrne

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Citations

Jan 1, 1982·Annals of the New York Academy of Sciences·M BigazziM Farnararo
Nov 1, 1981·The Australian & New Zealand Journal of Obstetrics & Gynaecology·A H MacLennan
May 1, 1992·Archives of Biochemistry and Biophysics·G K ReddyS C Kwok

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