Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder.

Schizophrenia Bulletin
Mathias ValstadTorbjørn Elvsåshagen

Abstract

Several lines of research suggest that impairments in long-term potentiation (LTP)-like synaptic plasticity might be a key pathophysiological mechanism in schizophrenia (SZ) and bipolar disorder type I (BDI) and II (BDII). Using modulations of visually evoked potentials (VEP) of the electroencephalogram, impaired LTP-like visual cortical plasticity has been implicated in patients with BDII, while there has been conflicting evidence in SZ, a lack of research in BDI, and mixed results regarding associations with symptom severity, mood states, and medication. We measured the VEP of patients with SZ spectrum disorders (n = 31), BDI (n = 34), BDII (n = 33), and other BD spectrum disorders (n = 2), and age-matched healthy control (HC) participants (n = 200) before and after prolonged visual stimulation. Compared to HCs, modulation of VEP component N1b, but not C1 or P1, was impaired both in patients within the SZ spectrum (χ 2 = 35.1, P = 3.1 × 10-9) and BD spectrum (χ 2 = 7.0, P = 8.2 × 10-3), including BDI (χ 2 = 6.4, P = .012), but not BDII (χ 2 = 2.2, P = .14). N1b modulation was also more severely impaired in SZ spectrum than BD spectrum patients (χ 2 = 14.2, P = 1.7 × 10-4). N1b modulation was not significantly associated with ...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Sep 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A K MalhotraA Breier
Jan 14, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J W NewcomerJ W Olney
Jun 23, 2004·Nature Reviews. Neuroscience·Michael A Rogawski, Wolfgang Löscher
May 5, 2005·The European Journal of Neuroscience·Timothy J TeylerIan J Kirk
Jan 24, 2006·Biological Psychiatry·Klaas E StephanKarl J Friston
Apr 28, 2006·Neuroreport·Nicolas A McNairIan J Kirk
Aug 2, 2006·Neuron·Mikhail Y FrenkelMark F Bear
Jan 24, 2007·Biological Psychiatry·Claus NormannMichael Bach
May 16, 2008·Epidemiologic Reviews·John McGrathJoy Welham
Oct 15, 2009·Epilepsy Research·Chrysanthy Ikonomidou, Lechoslaw Turski
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sam F Cooke, Mark F Bear
Mar 9, 2011·Archives of General Psychiatry·Kathleen R MerikangasZahari Zarkov
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bita Moghaddam, Daniel Javitt
Nov 1, 2011·Biological Psychiatry·Torbjørn ElvsåshagenStein Andersson
Mar 1, 2012·Biological Psychiatry·Idil CavuşDaniel H Mathalon
Mar 5, 2013·Lancet·UNKNOWN Cross-Disorder Group of the Psychiatric Genomics Consortium
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium
Aug 26, 2014·Biological Psychiatry·Jeremy HallMichael J Owen
Mar 21, 2015·Journal of Neuroscience Methods·Maximilien ChaumonNiko A Busch
Jan 1, 2013·Trends in psychiatry and psychotherapy·José Caetano Dell'AglioAdriane Arteche
Jul 8, 2015·Frontiers in Neuroinformatics·Nima Bigdely-ShamloKay A Robbins
May 3, 2019·Nature Genetics·Eli A StahlUNKNOWN Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
Aug 23, 2019·Schizophrenia Research·Jonathan K WynnMichael F Green
Dec 14, 2019·Cell·UNKNOWN Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu, UNKNOWN Cross-Disorder Group of the Psychiatric Genomics Consortium

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