Evidence for rejection of homograft cardiac valves in infants

The Journal of Thoracic and Cardiovascular Surgery
B RajaniN B Ratliff

Abstract

Concern about the durability of small homograft cardiac valves has been expressed by surgeons, and evidence has been found that homograft valves evoke a recipient immune response. We reviewed our experience with homograft valves for evidence of rejection. A search of our files revealed 11 homograft cardiac valves removed at reoperation and one at autopsy. Six valves were from adults, five were from infants, and one was from a 13-year-old child. Immunohistochemical studies with antibodies against smooth muscle actin, CD20, CD43, CD34, and CD68 were performed on the homografts containing inflammatory infiltrates. These valves happened to be the valves from the five infants. These five valves were also stained with Gram and Gomori's methenamine silver stains. The failed homografts from the adults and 13-year-old child showed leaflet calcification, fibrosis, and degeneration, but no inflammation. The valves from the infants all failed in less than 8 months. The valve leaflets were thickened, and the valve leaflets and aortic sleeves contained a hyperplastic intimal layer with numerous spindle cells positive for smooth muscle actin embedded in a glycosaminoglycan matrix. The homografts contained multiple foci of inflammation consist...Continue Reading

References

Apr 1, 1990·Transplantation·H el Khatib, F M Lupinetti
Aug 1, 1988·The Annals of Thoracic Surgery·O MatsukiD N Ross
Aug 1, 1995·The Annals of Thoracic Surgery·T FischleinB Reichart
Aug 1, 1995·The Annals of Thoracic Surgery·J D SmithM H Yacoub
Aug 1, 1995·The Annals of Thoracic Surgery·M ValenteG Thiene
Aug 1, 1995·The Annals of Thoracic Surgery·J NevesJ Q Melo
Aug 1, 1995·The Annals of Thoracic Surgery·A C YankahR Hetzer
Aug 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·F HoekstraW Weimar

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Citations

Dec 4, 2003·Current Problems in Cardiology·Lars G SvenssonDelos M Cosgrove
Jan 31, 2004·The Journal of Thoracic and Cardiovascular Surgery·Jan T ChristensonAfksendiyos Kalangos
Nov 18, 2000·The Annals of Thoracic Surgery·J F LegareD B Ross
Mar 28, 2001·The Annals of Thoracic Surgery·C G GeresteinA J Bogers
Jun 28, 2001·The Annals of Thoracic Surgery·J F BechtelH H Sievers
Jul 25, 2003·The Journal of Thoracic and Cardiovascular Surgery·John A HawkinsRobert E Shaddy
Aug 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Winfield WellsMark L Barr
Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·R W GraussM C DeRuiter
Apr 16, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S ChauvaudA Carpentier
Jul 1, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·P R VogtM I Turina
Jun 26, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Dörthe SchmidtSimon P Hoerstrup
Oct 26, 2011·Cells, Tissues, Organs·John M WainwrightStephen F Badylak
Mar 17, 2005·The Heart Surgery Forum·P M DohmenW Konertz
Jul 2, 2011·The Annals of Thoracic Surgery·Rachael W QuinnRichard A Hopkins
Oct 11, 2015·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Jennifer S WooBrian Reemtsen
Dec 29, 2015·Seminars in Thoracic and Cardiovascular Surgery·Narutoshi HibinoMark Galantowicz
Apr 17, 2007·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Richard Hopkins
Jul 31, 2004·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Joseph M Forbess
Feb 1, 2005·The Annals of Thoracic Surgery·David K HooperRobert E Shaddy
Oct 29, 2002·The Annals of Thoracic Surgery·Robert E Shaddy, John A Hawkins
Oct 29, 2002·The Annals of Thoracic Surgery·Alexander KadnerMarko Turina
Jul 4, 2001·The Journal of Thoracic and Cardiovascular Surgery·P BattenM H Yacoub
Sep 10, 1998·The Journal of Thoracic and Cardiovascular Surgery·M KawauchiS Takamoto
Sep 27, 2005·Transplantation Proceedings·M MirelliA Stella
Aug 26, 2015·The American Journal of Cardiology·Jose Maria OliverAngel Aroca
Jan 25, 2011·The Annals of Thoracic Surgery·John W BrownMark W Turrentine
Aug 25, 2009·The Annals of Thoracic Surgery·Takeshi KonumaRichard G Ohye
Aug 2, 2000·The Annals of Thoracic Surgery·R SodianJ E Mayer
Sep 25, 2015·Expert Reviews in Molecular Medicine·Andres Sanz-GarciaCarmen Escobedo-Lucea
Oct 26, 2005·The Annals of Thoracic Surgery·Zarry TavakkolRichard G Ohye
Dec 28, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M MirelliM D'Addato
Dec 22, 1999·The Journal of Surgical Research·F B OeiA J Bogers

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