PMID: 9186838May 1, 1997Paper

Evidence for secretory coupling of phosphatidylcholine molecular species to cholesterol in rat bile

Journal of Hepatology
F BerrJ Mössner

Abstract

Hepatocytes secrete cholesterol into bile within lipid vesicles of selected phosphatidylcholines, mainly palmitoyl-linoleoyl-phosphatidylcholines, palmitoleoyl-oleoyl-phosphatidylcholines and palmitoleoyl-arachidonyl-phosphatidylcholines, which could in part determine the secreted amount of cholesterol. To study whether increased secretion of cholesterol, as caused by manipulation of cholesterol synthesis rate, changes the composition of phosphatidylcholines secreted in bile. Livers from control rats (Control), rats fed pravastatin for 7 days (Pravastatin) and livers isolated 5-7 or 8-11 hours after pravastatin had been withdrawn (Rebound5-7h; Rebound8-11h) were isolated perfused during infusion of taurocholic acid (400 nmol/min/100 g rat), to study biliary secretion of bile salts, cholesterol and phosphatidylcholine molecular species. Bile salt secretion rate was similar in all four groups, secretion of cholesterol and phosphatidylcholines was similar in Control and Pravastatin. With duration of pravastatin withdrawal the secretion rates of phosphatidylcholine and cholesterol progressively increased by +38% and +122% in Rebound5-7h and by +70% and +300% in Rebound8-11h (vs Control), respectively. In parallel, the secretion rat...Continue Reading

References

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Citations

May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CarrellaP A Weinhold
Feb 19, 2000·Biochemical and Biophysical Research Communications·H JaegerF Berr
Sep 13, 2001·Alimentary Pharmacology & Therapeutics·S P PereiraR H Dowling

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