Evidence for selection at cytokine loci in a natural population of field voles (Microtus agrestis)

Molecular Ecology
Andrew K TurnerSteve Paterson

Abstract

Individuals in natural populations are frequently exposed to a wide range of pathogens. Given the diverse profile of gene products involved in responses to different types of pathogen, this potentially results in complex pathogen-specific selection pressures acting on a broad spectrum of immune system genes in wild animals. Thus far, studies into the evolution of immune genes in natural populations have focused almost exclusively on the Major Histocompatibility Complex (MHC). However, the MHC represents only a fraction of the immune system and there is a need to broaden research in wild species to include other immune genes. Here, we examine the evidence for natural selection in a range of non-MHC genes in a natural population of field voles (Microtus agrestis). We concentrate primarily on genes encoding cytokines, signalling molecules critical in eliciting and mediating immune responses and identify signatures of natural selection acting on several of these genes. In particular, genetic diversity within Interleukin 1 beta and Interleukin 2 appears to have been maintained through balancing selection. Taken together with previous findings that polymorphism within these genes is associated with variation in resistance to multiple...Continue Reading

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Mar 13, 2014·Parasitology·A K TurnerM Begon
Sep 15, 2012·Trends in Ecology & Evolution·Philip W Hedrick
Oct 29, 2015·Molecular Ecology·Catalina Gonzalez-QuevedoDavid S Richardson
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Dec 5, 2019·Parasitology Open·Diana C OutlawDaniel G Peterson
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Javier Pérez-GonzálezJosé Manuel Benítez-Medina

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