Evidence for selection at the fused1 locus of Drosophila americana.

Genetics
Jorge VieiraB Charlesworth

Abstract

We analyze genetic variation at fused1, a locus that is close to the centromere of the X chromosome-autosome (X/4) fusion in Drosophila americana. In contrast to other X-linked and autosomal genes, for which a lack of population subdivision in D. americana has been observed at the DNA level, we find strong haplotype structure associated with the alternative chromosomal arrangements. There are several derived fixed differences at fused1 (including one amino acid replacement) between two haplotype classes of this locus. From these results, we obtain an estimate of an age of approximately 0.61 million years for the origin of the two haplotypes of the fused1 gene. Haplotypes associated with the X/4 fusion have less DNA sequence variation at fused1 than haplotypes associated with the ancestral chromosome arrangement. The X/4 haplotypes also exhibit clinal variation for the allele frequencies of the three most common amino acid replacement polymorphisms, but not for adjacent silent polymorphisms. These patterns of variation are best explained as a result of selection acting on amino acid substitutions, with geographic variation in selection pressures.

References

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Aug 5, 2000·Genetics·J Vieira, B Charlesworth

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Citations

Jan 6, 2007·PloS One·Bryant F McAllister, Amy L Evans
Oct 19, 2004·Genetics·Enrique Santiago, Armando Caballero
Mar 23, 2002·Genome Génome / Conseil National De Recherches Canada·Bryant F McAllister
Jul 11, 2006·Journal of Molecular Evolution·Ramiro Morales-HojasJorge Vieira
Jun 5, 2008·Evolution; International Journal of Organic Evolution·Bryant F McAllisterChristian Schlötterer

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