Evidence for specific autoimmunity against sympathetic and parasympathetic nervous tissues in Type 1 diabetes mellitus and the relation to cardiac autonomic dysfunction

Diabetic Medicine : a Journal of the British Diabetic Association
Daniela Muhr-BeckerO Schnell

Abstract

There is growing evidence for the involvement of immunological factors in the pathogenesis of cardiac autonomic dysfunction in Type 1 diabetes mellitus (DM). To evaluate the presence of autoantibodies against autonomic nervous tissues and their relationship with tests of autonomic function, 64 newly diagnosed and 142 long duration Type 1 DM patients were investigated for sympathetic and parasympathetic ganglia (CF-SG and CF-PSG) autoantibodies with a complement-fixing indirect immunofluorescence technique. Five cardiac reflex tests were performed to assess autonomic function. Fifty-seven patients with neurological diseases other than diabetic neuropathy and 131 healthy control subjects were also tested for CF-SG and CF-PSG autoantibodies. CF-SG autoantibodies were observed in 47 (23%) and CF-PSG autoantibodies in 21 (10%) of 206 Type 1 DM patients (p < 0.001). In contrast, these autoantibodies were detected in 3 (5%) and 1 (2%) of patients with non-diabetic neurological diseases and 3 (2%) and 4 (3%) of control subjects (p < 0.01, p < 0.05, p < 0.0001, p < 0.05 vs Type 1 DM patients). All except two Type 1 DM patients with CF-PSG autoantibodies also presented with CF-SG autoantibodies. In diabetic patients with long duration, C...Continue Reading

Citations

Oct 30, 2013·Cardiovascular Diabetology·Oliver SchnellAntonio Ceriello
Sep 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·S SchmidM Hummel
Nov 13, 2013·Ocular Immunology and Inflammation·Manuel Garza LeonPedro Mario González-Madrigal
Aug 21, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Radu NegoesAlin Achim
Jul 21, 2009·Journal of Bacteriology·Veronika M Meier, Birgit E Scharf
Jul 3, 2004·Endocrinology·Antonella MaffeiPaul E Harris

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