Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

Brain Research
J E Haley, A H Dickenson

Abstract

We used in vivo electrophysiology and a model of more persistent nociceptive inputs to monitor spinal cord neuronal activity in anaesthetised rats to reveal the pharmacology of enhanced pain signalling. The study showed that all responses were blocked by non-selective antagonism of glutamate receptors but a selective and preferential role of the N-methyl-d-aspartate (NMDA) receptor in the prolonged plastic responses was clearly seen. The work lead to many publications, initially preclinical but increasingly from patient studies, showing the importance of the NMDA receptor in central sensitisation within the spinal cord and how this could relate to persistent pain states. This article is part of a Special Issue entitled SI:50th Anniversary Issue.

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Citations

Apr 22, 2017·The Journal of Pain : Official Journal of the American Pain Society·Tony L YakshH Ralph Snodgrass
Mar 2, 2018·Environmental Monitoring and Assessment·Muhammad Furqan AkhtarBushra Akhtar
Apr 21, 2017·Clinical Obstetrics and Gynecology·Aileen Pan, Mark Zakowski
Jun 8, 2018·British Journal of Pharmacology·Edward B Stevens, Gary J Stephens

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