Evidence for subtypes of freezing of gait in Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Kaylena A Ehgoetz MartensSimon J G Lewis

Abstract

The purpose of this study is to identify and characterize subtypes of freezing of gait by using a novel questionnaire designed to delineate freezing patterns based on self-reported and behavioral gait assessment. A total of 41 Parkinson's patients with freezing completed the Characterizing Freezing of Gait questionnaire that identifies situations that exacerbate freezing. This instrument underwent examination for construct validity and internal consistency, after which a data-driven clustering approach was employed to identify distinct patterns amongst individual responses. Behavioral freezing assessments in both dopaminergic states were compared across 3 identified subgroups. This novel questionnaire demonstrated construct validity (severity scores correlated with percentage of time frozen; r = 0.54) and internal consistency (Cronbach's α = .937), and thus demonstrated promising utility for identifying patterns of freezing that are independently related to motor, anxiety, and attentional impairments. Patients with freezing may be dissociable based on underlying neurobiological underpinnings that would have significant implications for targeting future treatments. © 2018 International Parkinson and Movement Disorder Society.

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Citations

Aug 17, 2019·Expert Review of Neurotherapeutics·Martijn L T M MüllerNicolaas I Bohnen
Oct 9, 2019·Journal of Parkinson's Disease·Sommer L Amundsen HuffmasterColum D MacKinnon
Nov 27, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Manuel Delgado-AlvaradoJon Infante
Sep 22, 2020·Fortschritte der Neurologie-Psychiatrie·Jochen KluckenWolfgang Jost
May 3, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Martina ManciniJorik Nonnekes
Oct 28, 2019·Brain : a Journal of Neurology·Daniel WeissSimon J G Lewis
Dec 18, 2018·Drugs & Aging·Lauren E Ryden, Simon J G Lewis
Oct 20, 2020·Journal of Parkinson's Disease·Kristin EconomouKaylena A Ehgoetz Martens
Nov 2, 2020·Journal of Neuroengineering and Rehabilitation·Amy MaslivecWilliam Young
Nov 25, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Xiaohui TangXijin Wang
Mar 5, 2021·Current Psychiatry Reports·Sandra Abou KassmAntoine Pelissolo
Mar 4, 2021·NPJ Parkinson's Disease·Nicholas D'CruzAlice Nieuwboer
Mar 23, 2021·Journal of Parkinson's Disease·Bauke W DijkstraAlice Nieuwboer
Jun 1, 2021·Journal of Parkinson's Disease·Dione Y L QuekKaylena A Ehgoetz Martens
Jun 9, 2021·Parkinsonism & Related Disorders·Daniel H LenchGonzalo J Revuelta
Aug 19, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Brad ManorJeffrey M Hausdorff
Dec 24, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Nicolaas I BohnenUNKNOWN MDS-Scientific Issues Committee
Jan 15, 2022·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marika FallaAlessio Di Fonzo

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