Evidence for suppression of spinal glial activation by dexmedetomidine in a rat model of monoarthritis

Clinical and Experimental Pharmacology & Physiology
Bo XuYu-Qiu Zhang

Abstract

1. Spinal glial cells play a key role in developing and maintaining allodynia and hyperalgesia following tissue inflammation. Dexmedetomidine, a highly selective α(2) -adrenoceptor (α(2) -AR) agonist, has exhibited a significant analgesic effect in various rodent models of chronic pain. However, whether spinal glial activation is involved in the analgesic effect of dexmedetomidine remains unknown. The present study investigated whether spinal administration of dexmedetomidine could antagonize glial activation in the spinal dorsal horn and attenuate thermal hyperalgesia in complete Freund's adjuvant (CFA)-induced ankle joint monoarthritic (MA) rats. 2. Unilateral intra-articular injection of CFA produced a robust activation of microglia and astrocytes in the spinal cord, which was associated with the development and maintenance of thermal hyperalgesia. Repeated lumbar puncture (LP) administration of dexmedetomidine (10 μg) significantly attenuated MA-induced thermal hyperalgesia in a cumulative manner. Monoarthritis-induced spinal glial activation was also suppressed following dexmedetomidine application. The α(2A) -AR, essential for the antinociceptive effects of α(2) -AR agonists, was detected in spinal neurons and glia, as we...Continue Reading

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Citations

Dec 14, 2011·Amino Acids·Franca Marino, Marco Cosentino
Dec 14, 2011·The Journal of Pain : Official Journal of the American Pain Society·Ken-Ichiro HayashidaJames C Eisenach
Apr 24, 2013·CNS Neuroscience & Therapeutics·Shuang-Shuang LiHua Xu
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Feb 20, 2021·Journal of Pharmacological Sciences·Taisuke KitanoKen-Ichi Otsuguro
May 17, 2021·Neuroscience and Biobehavioral Reviews·Diogo DominguiniFelipe Dal-Pizzol

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