PMID: 6976357Jan 1, 1982Paper

Evidence for T cell-dependent immunity to Bacteroides fragilis in an intraabdominal abscess model

The Journal of Clinical Investigation
A B OnderdonkD L Kasper

Abstract

It has been shown that active immunization of rats with the capsular polysaccharide of Bacteroides fragilis protects these animals against abscess development following intraperitoneal challenge with this species. Passive transfer of hyperimmune globulin from immunized animals to nonimmune recipients provided protection against B. fragilis bacteremia in challenged animals, but did not confer protection against abscess development. On the other hand, adoptive transfer of spleen cells from immunized animals to nonimmunized recipients resulted in protection against abscesses following challenge with B. fragilis. These data suggested that a T cell-dependent immune response was involved in protection against abscess development after immunization with B. fragilis capsular antigen. To determine the possible role of cell-mediated immunity prompted by the capsular antigen, inbred congenitally athymic OLA/Rnu rats and their phenotypically normal littermates were actively immunized. Despite the development of high titers of anti-B. fragilis capsular antibody, 100% of actively immunized athymic rats developed abscesses, as did 100% of unimmunized athymic control rats. However, no phenotypically normal littermate control rats that were act...Continue Reading

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May 1, 1977·Annals of Internal Medicine·B F Polk, D L Kasper
Jul 1, 1977·The Journal of Infectious Diseases·D L KasperB F Polk
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
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Citations

Feb 9, 2002·Current Opinion in Microbiology·Arthur O Tzianabos, Dennis L Kasper
Oct 7, 2006·Nature Reviews. Immunology·Sarkis K Mazmanian, Dennis L Kasper
Jan 1, 1992·Microbiology and Immunology·R JotwaniK Ueno
Oct 24, 2007·Antimicrobial Agents and Chemotherapy·J A PassarellP G Ambrose
Mar 1, 1985·The Journal of Clinical Investigation·D F ZaleznikD L Kasper
Aug 1, 1986·The Journal of Clinical Investigation·W G PowderlyR B Markham
Dec 1, 1995·The Journal of Clinical Investigation·A O TzianabosA B Onderdonk
Jan 1, 1994·FEMS Microbiology Reviews·I Brook
Dec 16, 2011·Immunological Reviews·Neeraj K Surana, Dennis L Kasper
Jan 15, 2014·Gut Microbes·Vincent L Chen, Dennis L Kasper
Jun 6, 2009·Biochemical and Biophysical Research Communications·J M B D VieiraR M C P Domingues
May 17, 2006·Anaerobe·Andrew B Onderdonk
Oct 1, 1995·Clinical Immunology and Immunopathology·R G SawyerT L Pruett
Mar 13, 2018·Annals of the New York Academy of Sciences·Deniz Erturk-Hasdemir, Dennis L Kasper
Sep 1, 1983·The British Journal of Surgery·A J McIrvineJ A Mannick
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·E AlbengresJ P Tillement
Jan 1, 1987·Critical Reviews in Microbiology·I Brook
Jul 27, 1989·The New England Journal of Medicine·B Styrt, S L Gorbach
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca StingeleArthur O Tzianabos
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·W M Kalka-MollD L Kasper
May 5, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bruno Jennings-AlmeidaAna Carolina Oliveira
May 1, 1986·Infection and Immunity·A C RodloffH Friedman
Feb 1, 1989·Infection and Immunity·G A RosenthalO D Rotstein
Dec 1, 1986·Microbiological Reviews·I Brook
Sep 16, 2021·Journal of Clinical Microbiology·Alexander J McAdam

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