Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration

Developmental Cell
K Somogyi, Pernille Rørth

Abstract

Cells migrating through a tissue exert force via their cytoskeleton and are themselves subject to tension, but the effects of physical forces on cell behavior in vivo are poorly understood. Border cell migration during Drosophila oogenesis is a useful model for invasive cell movement. We report that this migration requires the activity of the transcriptional factor serum response factor (SRF) and its cofactor MAL-D and present evidence that nuclear accumulation of MAL-D is induced by cell stretching. Border cells that cannot migrate lack nuclear MAL-D but can accumulate it if they are pulled by other migrating cells. Like mammalian MAL, MAL-D also responds to activated Diaphanous, which affects actin dynamics. MAL-D/SRF activity is required to build a robust actin cytoskeleton in the migrating cells; mutant cells break apart when initiating migration. Thus, tension-induced MAL-D activity may provide a feedback mechanism for enhancing cytoskeletal strength during invasive migration.

References

Feb 1, 1994·Current Opinion in Genetics & Development·R Treisman
Feb 11, 1999·The Journal of Cell Biology·P NiewiadomskaU Tepass
Mar 29, 2001·Physiological Reviews·O P Hamill, B Martinac
May 2, 2001·The Journal of Cell Biology·K KatohK Fujiwara
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T MercherO A Bernard
Aug 2, 2001·Biochemical and Biophysical Research Communications·K S Ko, C A McCulloch
Sep 15, 2001·Nature·P G Gillespie, R G Walker
Jan 24, 2002·Mechanisms of Development·Simone BeccariPernille Rørth
Aug 21, 2002·Trends in Cell Biology·Pernille Rørth
Aug 29, 2002·Nature Cell Biology·Tudor A Fulga, Pernille Rørth
Oct 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Da-Zhi WangEric N Olson
Dec 12, 2002·Molecular Biology of the Cell·Guido PosernRichard Treisman
Jan 30, 2003·Cell·Neal D Epstein, Julien S Davis
May 7, 2003·Cell·Francesc MirallesRichard Treisman
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Alexander D BershadskyBenjamin Geiger

❮ Previous
Next ❯

Citations

Aug 18, 2012·Journal of Cardiovascular Translational Research·Eric M Small
Jul 13, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Nikolce GjorevskiCeleste M Nelson
Nov 28, 2013·Nature Communications·Thibaut BrunetEmmanuel Farge
May 3, 2005·Nature Reviews. Cancer·Honami Naora, Denise J Montell
Sep 21, 2013·Nature Reviews. Genetics·Callie Johnson Miller, Lance A Davidson
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Michele A Wozniak, Christopher S Chen
Sep 25, 2012·Nature Reviews. Molecular Cell Biology·Denise J MontellMichelle Starz-Gaiano
Mar 6, 2007·Nature Structural & Molecular Biology·Marcelo NöllmannNicholas R Cozzarelli
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Wesley R LegantChristopher S Chen
Oct 23, 2009·Molecular Biology of the Cell·Catarina C F Homem, Mark Peifer
Nov 19, 2010·Cold Spring Harbor Perspectives in Biology·Martin Alexander Schwartz
Jul 19, 2006·Molecular and Cellular Biology·Yi SunStephan W Morris
Jan 10, 2008·Annual Review of Cell and Developmental Biology·R Grant Rowe, Stephen J Weiss
Feb 8, 2006·Annual Review of Physiology·Daniel J Tschumperlin, Jeffrey M Drazen
Feb 5, 2011·Circulation Research·Mark W MajeskyVirginia J Hoglund
Aug 4, 2011·Disease Models & Mechanisms·William RazzellPaul Martin
Apr 21, 2010·PloS One·Barry J Thompson
Apr 25, 2014·PloS One·Sabine C FischerNicole Gorfinkiel
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catherine PawsonGraeme W Davis
Apr 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Siegfried AlbertiAlfred Nordheim
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhe HanEric N Olson
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cynthia J SchoenMarci M Lesperance
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Boris I Shraiman
Sep 1, 2005·The Journal of Cell Biology·Anne Pacquelet, Pernille Rørth
Jun 5, 2013·The Journal of Cell Biology·Eliana P LucasBarry J Thompson
Jun 10, 2009·The Journal of Cell Biology·Stephen J Warner, Gregory D Longmore
Jul 4, 2012·Seminars in Cell & Developmental Biology·Molly C Schroeder, Georg Halder
Mar 6, 2012·The International Journal of Biochemistry & Cell Biology·Melissa G Mendez, Paul A Janmey
May 11, 2010·Current Opinion in Genetics & Development·Hernán López-Schier
Oct 18, 2015·Seminars in Cell & Developmental Biology·Hiroshi Hamada
Oct 14, 2008·Trends in Cell Biology·R Grant Rowe, Stephen J Weiss
Nov 27, 2007·Experimental Cell Research·Takanori KiharaMasayuki Murata
May 17, 2005·Journal of Thrombosis and Haemostasis : JTH·C P Mack, J S Hinson
Jun 15, 2005·Journal of Neurochemistry·Akiko TabuchiJay M Baraban
May 9, 2009·Scandinavian Journal of Medicine & Science in Sports·M B AsparuhovaM Chiquet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.