Evidence for the ancient origin of the NF-kappaB/IkappaB cascade: its archaic role in pathogen infection and immunity

Proceedings of the National Academy of Sciences of the United States of America
Xiao Wei WangJeak Ling Ding

Abstract

The evolutionary conservation of the NF-kappaB transcription factors, from Drosophila to humans, underscores its pivotal role in immune response. Unexpectedly, the canonical NF-kappaB signaling pathway is not functional in the immune system of Caenorhabditis elegans. Therefore, the ancient origin of the NF-kappaB signaling pathway is still unknown. Here, we report the discovery and characterization of a primitive and functional NF-kappaB/IkappaB pathway in the immune defense of a "living fossil," the horseshoe crab, Carcinoscorpius rotundicauda. The ancient NF-kappaB/IkappaB homologues, CrNFkappaB, CrRelish, and CrIkappaB, share numerous signature motifs with their vertebrate orthologues. CrNFkappaB recognizes both horseshoe crab and mammalian kappaB response elements. CrIkappaB interacts with CrNFkappaB and inhibits its nuclear translocation and DNA-binding activity. The activation of the CrNFkappaB is autoregulated by a feedback mechanism mediated by CrIkappaB, the natural inhibitor of CrNFkappaB. We further show that Gram-negative bacteria infection causes rapid degradation of CrIkappaB and nuclear translocation of CrNFkappaB. Infection also leads to an increase in the kappaB-binding activity and up-regulation of immune-rela...Continue Reading

References

May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Sep 12, 2000·Current Opinion in Genetics & Development·S A Wasserman
Jul 14, 2001·Trends in Biotechnology·J L Ding, B Ho
Sep 29, 2001·Nature Immunology·C Bogdan
Jan 16, 2002·Current Opinion in Immunology·Sadaaki Iwanaga
Jan 29, 2002·Nature Immunology·Jules A Hoffmann, Jean-Marc Reichhart
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sang Woon ShinAlexander S Raikhel
Dec 5, 2002·Cell·Vishva Dixit, Tak W Mak
Nov 7, 2003·Nature·Jules A Hoffmann
Nov 19, 2003·European Journal of Biochemistry·Narudo KawaiHideyoshi Yokosawa
Jan 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shigeru ArikiShun-ichiro Kawabata
May 4, 2004·Nature Reviews. Molecular Cell Biology·Lin-Feng Chen, Warner C Greene
May 18, 2004·Trends in Immunology·Giuseppina Bonizzi, Michael Karin
Jun 2, 2004·Cellular and Molecular Life Sciences : CMLS·T Osaki, S Kawabata
Jun 17, 2004·Journal of Endotoxin Research·Patricia M L NgJeak L Ding
Jun 18, 2004·Immunological Reviews·Kei-ichiro InamoriShun-ichiro Kawabata
Jan 18, 2005·Current Opinion in Immunology·Dennis H Kim, Frederick M Ausubel
Feb 22, 2005·The Journal of Biological Chemistry·Sang Woon ShinAlexander S Raikhel

❮ Previous
Next ❯

Citations

Aug 9, 2013·Apoptosis : an International Journal on Programmed Cell Death·Christopher J CoatesJacqueline Nairn
Mar 9, 2011·Nature Reviews. Microbiology·Masmudur M Rahman, Grant McFadden
Oct 31, 2006·Oncogene·S Minakhina, R Steward
Jul 30, 2009·Molecular Biology and Evolution·Jirí NehybaHenry R Bose
Oct 29, 2010·Journal of Virology·Katharine Fagan-Garcia, Michele Barry
Apr 28, 2007·American Journal of Respiratory and Critical Care Medicine·Stephen J ChapmanAdrian V S Hill
Aug 7, 2007·PLoS Genetics·Monica M HorvathDouglas A Bell
Jun 21, 2013·PloS One·Laëtitia MinguezLaure Giambérini
Mar 7, 2014·Nitric Oxide : Biology and Chemistry·Cintia M de BarrosSilvana Allodi
Aug 28, 2009·Cell and Tissue Research·Cintia Monteiro de BarrosSilvana Allodi
May 31, 2011·Frontiers in Bioscience (Landmark Edition)·Leonid L Moroz, Andrea B Kohn
Jul 31, 2010·International Journal of Immunogenetics·F LiL Song
May 19, 2009·Biochemical Pharmacology·Florence FolmerMarc Diederich
Apr 25, 2015·Molecular Biology and Evolution·William J Palmer, Francis M Jiggins
Aug 7, 2007·Developmental and Comparative Immunology·C MontagnaniJ M Escoubas
Nov 6, 2007·Molecular Immunology·Loh Wei-Ching BelindaDing Jeak Ling
Mar 23, 2012·Immunological Reviews·Michael HinzClaus Scheidereit
Mar 23, 2012·Immunological Reviews·Thomas D Gilmore, Francis S Wolenski
Aug 15, 2006·The Journal of Biological Chemistry·Karim IskanderAnil K Jaiswal
Jul 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shaochun YuanAnlong Xu
Jun 9, 2017·Proceedings. Biological Sciences·Gonçalo Santos-MatosÉlio Sucena
Nov 23, 2017·Fish & Shellfish Immunology·Mingjia YuJun Li
Jun 6, 2016·Biochemical Pharmacology·Jerome Reboul, Jonathan J Ewbank
Aug 7, 2017·Marine Pollution Bulletin·Cintia Monteiro de BarrosSilvana Allodi
Oct 9, 2007·Biochemical Pharmacology·Florence FolmerMarc Diederich
May 26, 2009·Fish & Shellfish Immunology·Xian-De HuangJian-Guo He
Oct 29, 2021·The FEBS Journal·Ankita SarkarPiyali Mukherjee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.