Evidence for the biclonal nature of a Waldenstrom's macroglobulinemia

Clinica Chimica Acta; International Journal of Clinical Chemistry
L BonewaldA C Wang


The serum of a patient with Waldenstrom's macroglobulinemia was shown to contain two IgM(kappa) paraproteins of different electrophoretic mobilities on cellulose acetate and immunoelectrophoresis and were designated IgM slow (s) and IgM fast (f). Both existed as high molecular weight polymers and contained a J chain. The two pentameric IgM monoclonal proteins were shown to be completely distinct in carbohydrate composition as determined by gas chromatography and periodic acid-Schiff staining, in molecular weight, by physicochemical properties, peptide mapping, amino-acid composition, NH2-terminal sequence, subgroup of light chains, and by lack of shared idiotypic determinants as determined by hemagglutination inhibition studies. Our study presents strong evidence for the 'bioclonal' nature of this gammopathy. We conclude that both paraproteins are distinct and originated from different B cells.


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Dec 29, 2006·The New England Journal of Medicine·Mandakolathur R MuraliKarin E Finberg
Nov 13, 2020·PloS One·Macarena Boiza-SánchezSocorro María Rodríguez-Pinilla
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jitra KriangkumLinda M Pilarski
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Related Concepts

Chromatography, Gas-Liquid
Kappa-Immunoglobulin Subgroup VK-21
Familial Waldenstrom's Macroglobulinaemia

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