PMID: 6539163Jul 1, 1984Paper

Evidence for the clonal origin of acquired hypomegakaryocytic thrombocytopenic purpura from a sex chromosome mosaic

Cancer Genetics and Cytogenetics
M NieneltowR Hoffman

Abstract

Cytogenetic studies performed on a 79-year-old female presenting with clinical and hematologic features of acquired hypomegakaryocytic thrombocytopenic purpura revealed sex chromosome mosaicism in blood lymphocytes (45,X/46,XX/47,XXX). The presence of only 45,X cells in the bone marrow is consistent with a unicellular origin of acquired hypomegakaryocytic thrombocytopenia in this patient. These studies also suggest that, in some instances, this disorder may originate at the level of the pluripotent hematopoietic stem cell.

References

Oct 21, 1976·The New England Journal of Medicine·J W AdamsonL Steinmann
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·P J FialkowA Yoshida
Aug 1, 1980·Annals of Internal Medicine·H P Koeffler, D W Golde
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Feb 1, 1982·Cancer Genetics and Cytogenetics·G Tricot, H Van Den Berghe
Feb 1, 1981·Annals of Internal Medicine·D B StollS Murphy

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