Evidence for the Effect of Vaccination on Host-Pathogen Interactions in a Murine Model of Pulmonary Tuberculosis by Mycobacterium tuberculosis.

Frontiers in Immunology
Zyanya Lucia Zatarain-BarrónDick Van Soolingen

Abstract

The global control of Tuberculosis remains elusive, and Bacillus Calmette-Guérin (BCG) -the most widely used vaccine in history-has proven insufficient for reversing this epidemic. Several authors have suggested that the mass presence of vaccinated hosts might have affected the Mycobacterium tuberculosis (MTB) population structure, and this could in turn be reflected in a prevalence of strains with higher ability to circumvent BCG-induced immunity, such as the recent Beijing genotype. The effect of vaccination on vaccine-escape variants has been well-documented in several bacterial pathogens; however the effect of the interaction between MTB strains and vaccinated hosts has never been previously described. In this study we show for the first time the interaction between MTB Beijing-genotype strains and BCG-vaccinated hosts. Using a well-controlled murine model of progressive pulmonary tuberculosis, we vaccinated BALB/c mice with two different sub-strains of BCG (BCG-Phipps and BCG-Vietnam). Following vaccination, the mice were infected with either one of three selected MTB strains. Strains were selected based on lineage, and included two Beijing-family clinical isolates (strains 46 and 48) and a well-characterized laboratory st...Continue Reading

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Citations

Nov 15, 2020·Clinical and Experimental Immunology·A KoushaL Sahebi
Jul 3, 2021·International Journal of Molecular Sciences·Jacqueline V Lara-EspinosaRogelio Hernández-Pando

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Datasets Mentioned

BETA
PRJNA628024

Methods Mentioned

BETA
RNA-seq
DNA-seq

Software Mentioned

BWA
Trimmomatic
CLC Genomics Workbench
Prokka
Qubit
DESeq2
MEM
QWin Leica
Snippy
GraphPad Prism

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