PMID: 6167437Jan 1, 1981Paper

Evidence for the existence of a family of bacterial nitroreductases capable of activating nitrated polycyclics to mutagens

Environmental Mutagenesis
E C McCoyR Mermelstein

Abstract

A derivative of Salmonella typhimurium TA98 which does not respond to the potent mutagenicity of 1,8-dinitropyrene is described. This novel strain also shows a lack of response to the mutagenic action of 1,3-dinitropyrene and a greatly reduced response to 1,6-dinitropyrene and 1-nitropyrene. The responses to 1,3,6-trinitropyrene and 1,3,6,8-tetranitropyrene are affected to a much lesser extent. This strain (TA98/1,8DNP6) is fully sensitive to the mutagenicity of 4-nitroquinoline-1-oxide, niridazole, nitroacridine, and nonnitrated frameshift mutagens. This strain appears to be deficient in a nitroreductase which reduces nitrated pyrenes and possibly other nitrated polycyclic aromatic hydrocarbons to corresponding hydroxylamines, the penultimate mutagens.

References

Jul 1, 1978·Cancer Letters·Y Y WangE T Wei
Sep 16, 1975·Biochemical and Biophysical Research Communications·H S Rosenkranz, W T Speck
Jun 1, 1981·Mutation Research·E C McCoyR Mermelstein
Jan 1, 1981·International Journal of Environmental Analytical Chemistry·D SchuetzleT J Prater

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Citations

May 1, 1984·Chemico-biological Interactions·D W BryantB E McCarry
May 1, 1984·Mutation Research·G Klopman, H S Rosenkranz
Sep 1, 1988·Mutation Research·B Beije, L Möller
May 1, 1983·Mutation Research·D M Maron, B N Ames
Jul 1, 1981·Mutation Research·R MermelsteinH S Rosenkranz
Feb 1, 1983·Mutation Research·E C McCoyR Mermelstein
May 1, 1983·Mutation Research·R Nagel, I Nepomnaschy
Jan 1, 1989·Mutation Research·B S Shane, A L Looney
Feb 1, 1990·Mutation Research·H Rodriguez, G L Murison
Mar 1, 1994·Mutation Research·S J SantosA T Natarajan
Apr 1, 1987·Mutation Research·B ZielinskaC V Hanson
May 1, 1987·Mutation Research·R Nagel
Aug 1, 1989·Mutation Research·E ClonferoA G Levis
Jun 1, 1991·Mutation Research·A MatsudaT Ueda

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