Evidence for the histamine-mediated myotropic effect of angiotensin II in the rabbit aorta

Z S ErcanR K Türker


Histamine H1-receptor antagonist mepyramine and H2-receptor antagonist metiamide, respectively diminished and potentiated angiotensin II(A II)-induced myotropic responses in the rabbit aortic strips. The responses of the octapeptide were also inhibited in the presence of histidine decarboxylase inhibitor, 2-hydroxy-5-carbomethoxybenzoxyamine and restored when subcontractile quantities of histamine are added to the inhibitor-containing medium. Inhibition of histamine degradation by aminoguanidine potentiates A II's responses. These results are taken as evidences indicating A II-induced histamine synthesis in the test preparation.


Sep 1, 1983·Pharmacological Research Communications·G CoruzziB Starcich

Related Concepts

Metiamide Monohydrochloride
Smooth Muscle
Chinchilla Rabbits
Antihistamines, Classical
Angiotensin II, Val(5)-
Histidine Decarboxylase
Histamine H2 Antagonists

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