Evidence for the Integration of Stress-Related Signals by the Rostral Posterior Hypothalamic Nucleus in the Regulation of Acute and Repeated Stress-Evoked Hypothalamo-Pituitary-Adrenal Response in Rat

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Tara J NyhuisSerge Campeau

Abstract

A likely adaptive process mitigating the effects of chronic stress is the phenomenon of stress habituation, which frequently reduces multiple stress-evoked responses to the same (homotypic) stressor experienced repeatedly. The current studies investigated putative brain circuits that may coordinate the reduction of stress-related responses associated with stress habituation, a process that is inadequately understood. Initially, two rat premotor regions that respectively regulate neuroendocrine (medial parvicellular region of the paraventricular hypothalamic nucleus [PaMP]) and autonomic (rostral medullary raphe pallidus [RPa]) responses were targeted with distinguishable retrograde tracers. Two to 3 weeks later, injected animals underwent loud noise stress, and their brains were processed for fluorescent immunohistochemical detection of the tracers and the immediate early gene Fos. A rostral region of the posterior hypothalamic nucleus (rPH), and to a lesser extent, the median preoptic nucleus, exhibited the highest numbers of retrogradely labeled cells from both the RPa and PaMP that were colocalized with loud noise-induced Fos expression. Injections of an anterograde tracer in the rPH confirmed these connections and suggested...Continue Reading

Citations

Jan 5, 2017·Biological & Pharmaceutical Bulletin·Tomoyoshi MiyamotoAtsufumi Kawabata
Aug 28, 2020·Stress : the International Journal on the Biology of Stress·Firdaus S DhabharRobert L Spencer
Dec 22, 2020·Stress : the International Journal on the Biology of Stress·James P HermanEvelin M Cotella
Feb 16, 2021·Stress : the International Journal on the Biology of Stress·Russell D Romeo, Rose K Sciortino

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