PMID: 9550289Apr 29, 1998Paper

Evidence for the involvement of multiple mechanisms in the excitatory action of bradykinin in the circular muscle of guinea-pig colon

Naunyn-Schmiedeberg's Archives of Pharmacology
V ZagorodnyukC A Maggi

Abstract

We have investigated, by using the sucrose gap technique, the mechanisms of the excitatory action of bradykinin in the circular muscle of the guinea-pig proximal colon. In the presence of atropine (1 microM) and S-ketoprofen (3 microM), the application of bradykinin (1 microM for 20 s) produced complex changes in membrane potential and muscle tension. The prevailing response was a small hyperpolarization followed by a slowly developing depolarization and a tonic contraction. The selective B2 receptor antagonist, HOE 140 (0.3 microM) blocked the responses to bradykinin (1 microM) while tetrodotoxin (0.3 microM) had no affect. The selective B1 receptor agonist, [des-Arg9]bradykinin (1 microM) did not affect the electrical or mechanical activities of the circular muscle. Apamin (0.1 microM) blocked the transient hyperpolarization and potentiated the bradykinin-induced depolarization and contraction. In the presence of apamin, nifedipine (1 microM) blocked spikes (when present) and the phasic contraction while leaving the tonic contraction unaffected. The excitatory action of bradykinin was further investigated in the presence of atropine (1 microM), S-ketoprofen (3 microM), apamin (0.1 microM) and nifedipine (1 microM). The depola...Continue Reading

Citations

Jan 5, 2000·European Journal of Pharmacology·S N SukhanovA T Ferreira
Mar 1, 2012·European Journal of Pharmacology·Matthias Rehn, Martin Diener
Oct 27, 2015·The Journal of Veterinary Medical Science·Yasuyuki TanahashiSeiichi Komori
Jun 8, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L Würner, M Diener
Oct 29, 2011·Biology of Reproduction·Patrick J DevineUlrike Luderer

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