Evidence for the involvement of Par-4 in ischemic neuron cell death

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
C CulmseeM P Mattson

Abstract

After a stroke many neurons in the ischemic brain tissue die by a process called apoptosis, a form of cell death that may be preventable. The specific molecular cascades that mediate ischemic neuronal death are not well understood. The authors recently identified prostate apoptosis response-4 (Par-4) as a protein that participates in the death of cultured hippocampal neurons induced by trophic factor withdrawal and exposure to glutamate. Here, the authors show that Par-4 levels increase in vulnerable populations of hippocampal and striatal neurons in rats after transient forebrain ischemia; Par-4 levels increased within 6 hours of reperfusion and remained elevated in neurons undergoing apoptosis 3 days later. After transient focal ischemia in mice, Par-4 levels were increased 6 to 12 hours after reperfusion in the infarcted cortex and the striatum, and activation of caspase-8 occurred with a similar time course. Par-4 immunoreactivity was localized predominantly in cortical neurons at the border of the infarct area. A Par-4 antisense oligonucleotide protected cultured hippocampal neurons against apoptosis induced by chemical hypoxia and significantly reduced focal ischemic damage in mice. The current data suggest that early up-...Continue Reading

References

Aug 1, 1995·Brain Research. Molecular Brain Research·M D LinnikK K Schroeder
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·M D LinnikM D Hatfield
Sep 1, 1996·Journal of Neurochemistry·E M MillsG E Isom
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·A N MurphyG Fiskum
Jul 1, 1997·Molecular and Cellular Biology·S F SellsV M Rangnekar
Oct 6, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C K PetitoW A Pulsinelli
Dec 9, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M EndresM A Moskowitz
May 2, 1998·The EMBO Journal·C ScaffidiM E Peter
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·Q GuoM P Mattson
May 6, 1998·Current Opinion in Neurobiology·L Bergeron, J Yuan
May 20, 1998·Journal of the Neurological Sciences·Y LiM Chopp
Sep 18, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y ZhuJ Krieglstein
Oct 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K FinkM A Moskowitz
Oct 31, 1998·Current Opinion in Immunology·M E Peter, P H Krammer
Apr 2, 1999·Trends in Pharmacological Sciences·P NicoteraL Manzo
Apr 10, 1999·The Journal of Biological Chemistry·S FrutosM T Diaz-Meco
Apr 22, 1999·Annals of Neurology·J B SchulzM A Moskowitz
Jun 8, 1999·Annual Review of Immunology·D WallachM P Boldin
Jul 8, 1999·The American Journal of Pathology·I I KrumanM P Mattson
Jul 21, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S MatsumotoT Wieloch
Jul 31, 1999·The Journal of Biological Chemistry·C ScaffidiM E Peter
Aug 11, 1999·Trends in Neurosciences·U DirnaglM A Moskowitz
Aug 24, 1999·Neurochemistry International·N Marks, M J Berg
Sep 24, 1999·Journal of Neuroscience Research·S L Chan, M P Mattson
Oct 3, 1999·Physiological Reviews·P Lipton
Feb 26, 2000·Journal of Molecular Neuroscience : MN·M P MattsonS Camandola
Apr 14, 2000·Brain Pathology·G S RobertsonJ B Schulz
Apr 27, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W A PedersenM P Mattson
Aug 6, 2000·Cell and Tissue Research·M P MattsonZ F Yu
Feb 13, 2001·The Journal of Clinical Investigation·M P Mattson, S Camandola

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Citations

Apr 9, 2005·Experimental Cell Research·Susanne VetterkindUte Preuss
Feb 5, 2003·Experimental Cell Research·Nadia El-Guendy, Vivek M Rangnekar
May 24, 2003·Trends in Molecular Medicine·Mark P Mattson, Guido Kroemer
Jun 28, 2003·Neurotoxicity Research·Iñigo AzcoitiaLuis M Garcia-Segura
Aug 5, 2003·Molecular and Cellular Biology·Nadia El-GuendyVivek M Rangnekar
Feb 19, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ling-Hsuan WangChia-Hsiang Chen
Oct 13, 2009·CNS Neuroscience & Therapeutics·Xin Wang
Oct 16, 2012·Expert Opinion on Therapeutic Targets·Rosalyn B Irby, Christina L B Kline
Jun 4, 2014·Expert Opinion on Therapeutic Targets·Wu QinanChen Bing
Aug 8, 2007·The International Journal of Neuropsychopharmacology·Shirly AmarGalila Agam
Jul 5, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dali YinJohn H Zhang
Apr 17, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nikolaus PlesnilaKlas Blomgren
Apr 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rachel KennySarah J Spencer
Jul 14, 2001·The Journal of Biological Chemistry·X WangC Vincenz
Oct 25, 2016·Molecular Neurobiology·Svetlana Demyanenko, Anatoly Uzdensky
Nov 25, 2003·The Journal of Biological Chemistry·Qing Guo, Jun Xie
Nov 1, 2006·Biochemical Society Transactions·C Culmsee, N Plesnila
Jan 1, 2013·Brain Sciences·Sarah J SpencerZane B Andrews
Jul 1, 2019·Apoptosis : an International Journal on Programmed Cell Death·Anatoly B Uzdensky

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Methods Mentioned

BETA
electrophoresis
antisense oligonucleotide
antisense oligonucleotides

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