Evidence for the involvement of the central adrenergic system in the febrile response induced by interleukin-1 in rats

Journal of Neuroimmunology
H OvadiaJ Weidenfeld

Abstract

We have studied the effect of noradrenaline- and serotonin-depleting agents on the febrile response induced by an intracerebroventricular (i.c.v.) injection of interleukin-1 (IL-1) in rats. Pretreatment with an injection into the lateral ventricle of the catecholamine-depleting agent, 6-hydroxydopamine (6-OHDA), abolished the febrile response induced by IL-1. Injection of 6-OHDA into the ventral noradrenergic ascending bundle (VNAB) did not affect the pyrogenic effect of IL-1. Pretreatment with the serotonin-depleting agent, 5,7-dihydroxytryptamine (5,7-DHT), did not inhibit the febrile response to IL-1. In addition, pretreatment with a beta-adrenergic blocker (propranolol) but not an alpha-adrenergic blocker (yohimbine) attenuated the fever induced by an i.c.v. injection of IL-1. These results suggest that the integrity of the central catecholaminergic system is important in mediating the IL-1-induced fever in rats. The central serotonergic system, as well as noradrenergic neurotransmission at the hypothalamus, do not appear to participate in this endogenous pyrogen-induced febrile response.

References

Jun 12, 1978·Annals of the New York Academy of Sciences·R D Myers
Jan 1, 1979·Experimental Eye Research·T N Thomas, D A Redburn
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·B Cox
Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·M Göthert, G Weinheimer
Apr 1, 1978·Pharmacology, Biochemistry, and Behavior·R D Myers, W D Ruwe
May 1, 1975·Angewandte Chemie·W Bartmann
Aug 1, 1986·Endocrine Reviews·R M SapolskyB S McEwen
Nov 1, 1971·British Journal of Pharmacology·B N Dhawan, P R Dua
Oct 1, 1980·The Journal of Experimental Medicine·G RiveauL Chedid
Apr 1, 1982·Immunology Today·J J Oppenheim, I Gery

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Citations

Jan 1, 1994·Neuroscience and Biobehavioral Reviews·C W SimpsonR D Myers
Apr 2, 1998·Physiology & Behavior·D SoszynskiM J Kluger
Jul 17, 2007·Canadian Journal of Physiology and Pharmacology·Alexandre O Fernandes da SilvaLuiz G S Branco
May 18, 2004·The Journal of Physiology·Maria C AlmeidaLuiz G S Branco
Dec 9, 2008·Brain Research Reviews·Mark F Mehler, Dominick P Purpura
Dec 15, 2007·Clinical Neuroscience Research·Adrian J Dunn
Sep 5, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kênia C BicegoLuiz G S Branco
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C R Plata-Salamán
Aug 1, 1996·The American Journal of Physiology·C H LangT C Vary

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