Evidence for the involvement of the nitric oxide-cGMP pathway in the antinociception of morphine in the formalin test

European Journal of Pharmacology
Vinicio Granados-SotoS H Ferreira

Abstract

The effect of inhibition of nitric oxide synthesis and guanylate cyclase on the peripheral antinociceptive effect of morphine was assessed by using the formalin test in the rat. Saline, N(G)-monomethyl-L-arginine, a nitric oxide synthesis inhibitor (50 microg) and methylene blue, a guanylate cyclase inhibitor (500 microg), did not exhibit any antinociceptive activity. However, morphine (10 microg) produced a significant antinociceptive effect in phases 2a and 2b, which was reduced by pretreatment with either N(G)-monomethyl-L-arginine or methylene blue. These results suggest that the local administration of morphine induces antinociception by the activation of the L-arginine-nitric oxide-cGMP pathway.

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Citations

Jan 28, 2004·European Journal of Pharmacology·Ken-ichiro HayashidaEtsumori Harada
Jan 28, 2004·European Journal of Pharmacology·Myrna Déciga-Campos, Francisco J López-Muñoz
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Jul 29, 2000·European Journal of Pharmacology·T Mixcoatl-ZecuatlV Granados-Soto
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Aug 5, 2000·Journal of Pharmacological and Toxicological Methods·P Aguirre-Bañuelos, V Granados-Soto
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