PMID: 8971800Nov 29, 1996Paper

Evidence for the neuronal origin of immunoreactive interleukin-1 beta released by rat hypothalamic explants

Neuroscience Letters
G TringaliP Navarra

Abstract

In this study, we have investigated the release of immunoreactive interleukin-1 beta (irIL-1 beta) from the rat hypothalamus in vitro. It was found that (1) tissue explants release sizable amounts of irIL-1 beta (ranging from 0.43 to 0.52 pg/mg of wet tissue) in 20 min incubations; (2) basal release in significantly increased by depolarization induced with 56 mM KCl; (3) K(+)-induced irIL-1 beta release is inhibited by the specific blocker of N-type calcium channels, omega-conotoxin, and by verapamil, but not by nifedipine; (4) K(+)-induced release is also inhibited by the Na+ channel blockers tetrodotoxin and lidocaine; (5) irIL-1 beta release is significantly increased by noradrenalin; such increase is antagonized by verapamil and the beta-blocker propranolol, but not by the alpha-blocker phentolamine. The present evidence suggests that irIL-1 beta released by rat hypothalamic explants following KCl depolarization is neuronal in origin.

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Citations

Feb 18, 1999·Toxicology Letters·G TringaliP Navarra
Aug 9, 2005·International Journal of Behavioral Medicine·Miriam ArgamanShmuel Ariad
Dec 22, 2010·Journal of Psychiatry & Neuroscience : JPN·Stefano PorcelliAlessandro Serretti
Dec 21, 2010·Journal of Psychiatry & Neuroscience : JPN·Simon N Young
Mar 7, 2014·Antioxidants & Redox Signaling·Ana I RojoAntonio Cuadrado
Jan 11, 2005·Brain Research Bulletin·Terrence DeakSteven P Tammariello
Jun 10, 2003·Chembiochem : a European Journal of Chemical Biology·Natalya Lozovaya, Andrew D Miller
Feb 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aline S C FabricioPierluigi Navarra
Jan 22, 2003·Journal of Neuroendocrinology·C C Ferri, A V Ferguson
Aug 27, 2014·Alcoholism, Clinical and Experimental Research·Tamara L Doremus-FitzwaterTerrence Deak
Sep 5, 1998·The American Journal of Physiology·A V GourineM J Kluger

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