PMID: 16648905May 2, 2006Paper

Evidence for the participation of nitric oxide in pemphigus

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
M X SiebraF A C Rocha

Abstract

Pemphigus is an inflammatory autoimmune disorder of the skin. Nitric oxide (NO) is an inflammatory mediator linked to a variety of physiological and pathophysiological phenomena that include skin tumors, psoriasis, urticaria, and atopic dermatitis. Inflammatory cells present in pemphigus lesions are important sources of NO production. We investigated whether NO is involved in pemphigus. A prospective cohort study was conducted at the Dermatology Service of the Hospital Universitário Walter Cantídio of the Federal University of Ceará. All patients seen at the outpatient clinic between August 2000 and July 2001, with a clinically and histologically confirmed diagnosis of pemphigus were included. The median age was 42.5 years (range: 12-69 years) with a male to female ratio of 3:2. Total serum nitrite levels, used as a marker for NO production, were determined by the Griess reaction. Skin biopsies from pemphigus and breast surgery (control) patients were used for the detection of the inducible NO synthase (iNOS) by immunohistochemistry. Twenty-two (22) patients with pemphigus and eight (8) controls who did not differ in demographic characteristics were included. Total serum nitrite levels were significantly higher (>7 micromol/L) ...Continue Reading

References

Jan 1, 1989·The Journal of Investigative Dermatology·L A DiazC Lavrado
Jan 1, 1982·Acta Odontologica Scandinavica·J Hietanen
May 20, 1982·The New England Journal of Medicine·G J AnhaltL A Diaz
May 19, 1995·Chemico-biological Interactions·G L Squadrito, W A Pryor
Jan 1, 1995·The Journal of Investigative Dermatology·M Amagai
Jan 1, 1994·Methods in Enzymology·J S BeckmanJ P Crow
Feb 1, 1994·Biological Chemistry Hoppe-Seyler·J S BeckmannC R White
Jan 1, 1996·Methods in Enzymology·A van der VlietB Halliwell
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·L A MacMillan-CrowJ A Thompson
Jun 26, 2001·Allergy·S TaniuchiY Kobayashi
Sep 13, 2001·Journal of Cutaneous Pathology·M KagouraM Morohashi
Jan 29, 2002·Best Practice & Research. Clinical Rheumatology·S B AbramsonM Attur

❮ Previous
Next ❯

Citations

Dec 17, 2009·The Journal of Biological Chemistry·Steve MarchenkoSergei A Grando
May 29, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marzia CaproniPaolo Fabbri
May 15, 2008·The British Journal of Dermatology·M MarquinaM J López-Zabalza
Feb 14, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·Y YesilovaE Turan
Feb 17, 2015·Clinical and Experimental Dermatology·M H JavanbakhtC Chams-Davatchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

© 2022 Meta ULC. All rights reserved