Abstract
The internal anal sphincter tone is important for anorectal continence. This study examined the role of angiotensin II as a neurohumoral signal for the myogenic tone in the internal anal sphincter. We determined the effect of angiotensin I, II, III, and IV and angiotensin-(1-7) on the basal tone of the rat internal anal sphincter smooth muscle before and after selective receptor antagonists and biosynthesis inhibitors. Selective pharmacological tools used were losartan (for the AT(1) receptor), PD123,319 (for AT(2)), A-779 [for angiotensin-(1-7)], captopril (for angiotensin-converting enzyme), and amastatin (for aminopeptidases A and N). Angiotensins were measured by using high-performance liquid chromatography/UV. Western blot studies were used to determine AT(1) and AT(2) receptors, ACE, and aminopeptidases A and N. Angiotensin I, II, and III produced concentration-dependent contraction in the internal anal sphincter mediated by AT(1) receptors. However, in the higher concentrations (from 100 nM to 10 microM), angiotensin II showed an inhibitory effect via AT(2) receptors. Captopril (1 microM) inhibited the biosynthesis of angiotensin II in the internal anal sphincter, antagonized the contractile effects of angiotensin I, and...Continue Reading
References
Jan 1, 1978·Biochemical Pharmacology·M A Devynck, P Meyer
Jun 26, 1992·Brain Research·J W HardingJ W Wright
Jan 1, 1991·Gastroenterology·R KobayashiJ H Walsh
Jan 1, 1989·Pharmacotherapy·A L HumeS E Lauerman
Oct 1, 1985·Gastroenterology·P BiancaniJ Behar
Jan 1, 1982·Physiological Reviews·A J Kenny, S Maroux
Jan 1, 1994·Brain Research Bulletin·R A SantosC Gropen Júnior
Apr 1, 1996·Hypertension·R A SantosN C Baracho
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·S ZiniC Llorens-Cortes
Jan 4, 1998·Kidney International·R Ardaillou, D Chansel
Oct 31, 2000·Gastroenterology·W CaoP Biancani
Feb 14, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ya-Ping FanSatish Rattan
May 11, 2002·Life Sciences·Satish RattanRajinder N Puri
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Weibiao CaoPiero Biancani
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rajinder N PuriSatish Rattan
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Márcio A F de Godoy, Ana M de Oliveira
Oct 29, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Adriana Pelegrini-da-SilvaAntonio R Martins
Jul 10, 2003·Gastroenterology·Ramón BatallerJuan Rodés
Citations
Jan 14, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satish Rattan, Jagmohan Singh
Dec 6, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Márcio A F de GodoySatish Rattan
Feb 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Márcio A F de GodoySatish Rattan
Apr 19, 2011·Trends in Pharmacological Sciences·Márcio A F de Godoy, Satish Rattan
Nov 26, 2009·Gastroenterology·Satish RattanPinckney J Maxwell
Jan 24, 2007·Gastroenterology·Anna CasselbrantLars Fändriks
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Rattan
Aug 17, 2006·Acta Physiologica·S EwertL Fändriks
Nov 3, 2005·Experimental Physiology·S EwertL Fandriks
Oct 14, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A OpazoD Gallego
Jun 9, 2015·Acta Physiologica·M MastropaoloR Serio
May 24, 2012·TheScientificWorldJournal·Dorota Ptasinska-WnukHenryk Stepien
Dec 14, 2011·International Journal of Hypertension·Marcio Augusto Fressatto de GodoySatish Rattan
Mar 25, 2008·Journal of Pharmacological Sciences·Leposava GrbovicSrdan Pesic
Oct 13, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Shahram AlaRoja Qobadighadikolaei
Dec 10, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satish Rattan
Jan 29, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·A CasselbrantH Lönroth
Oct 29, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Lars Fändriks
Feb 3, 2005·The Journal of Biological Chemistry·Araceli Díaz-PeralesCarlos López-Otín
Jan 29, 2009·The American Journal of Gastroenterology·Osvaldo BorrelliSalvatore Cucchiara
Aug 7, 2007·Techniques in Coloproctology·E E Collins, J N Lund
Jul 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Márcio A F De Godoy, Satish Rattan
Aug 25, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Márcio A F de Godoy, Satish Rattan
Feb 26, 2013·Techniques in Coloproctology·M KhaikinS D Wexner
May 2, 2006·The Journal of Pharmacology and Experimental Therapeutics·Márcio A F De Godoy, Satish Rattan
Sep 21, 2006·The Journal of Pharmacology and Experimental Therapeutics·Márcio A F de Godoy, Satish Rattan
Jul 19, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chadalavada Vijay KrishnaSatish Rattan
Apr 18, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satish RattanBenjamin Phillips
Nov 5, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arjun SinghSatish Rattan
May 3, 2019·Scientific Reports·Ipsita MohantySatish Rattan
Jun 3, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arjun Singh, Satish Rattan