PMID: 6770410Jan 1, 1980

Evidence for the role of noradrenaline in some effects of quipazine

H FrancèsP Simon


In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These three responses are considered to be predictive of an antidepressive action; in these three tests the effects of quipazine are inhibited by D,L-propranolol but not by D-propranolol or methysergide. Quipazine, in mice pretreated with pargyline, induced head twitches which were inhibited by methysergide but not by D,L-propranolol. Quipazine, in addition to its well-known serotonergic effects, seems to have beta-adrenergic properties which should be kept in mind when this drug is used as a pharmacological tool and which suggest that the beta-adrenergic system is implied in depression.


Feb 1, 1976·The Journal of Pharmacy and Pharmacology·R M QuockE L Chan
Dec 29, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·J R Walters, R H Roth
Mar 1, 1977·Pharmacology, Biochemistry, and Behavior·J B MalickA Barnett
Nov 23, 1979·European Journal of Pharmacology·M SoutoP Simon
Jan 1, 1978·European Journal of Pharmacology·A J PuechP Simon
Jul 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·M HamonJ Glowinski
Nov 15, 1974·Biochemical Pharmacology·M GrabowskaJ Michaluk
Jun 1, 1972·Life Sciences. Pt. 1: Physiology and Pharmacology·R Rodríguez
Nov 1, 1973·European Journal of Pharmacology·R RodríguezR R Drucker-Colín
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Nov 1, 1981·Pharmacology, Biochemistry, and Behavior·S AhleniusJ L Nilsson
Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·P A Caza, L P Spear
Feb 1, 1985·Pharmacology, Biochemistry, and Behavior·L A Ristine, L P Spear
Jan 1, 1987·Pharmacology & Therapeutics·M F Sugrue
Jun 1, 1987·Behavioural Brain Research·M R PranzatelliS R Snodgrass

Related Concepts

Behavior, Animal
Norepinephrine, (+, -)-Isomer
Quipazine Maleate (1: 1)
Stereotyped Behavior
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