PMID: 6107363Sep 1, 1980Paper

Evidence for thermoregulatory dopaminergic receptors located in the preopticus medialis nucleus of the rat hypothalamus

The Journal of Pharmacy and Pharmacology
O Colboc, J Costentin

Abstract

Systemic administration of apomorphine induces hypothermia in anaesthetized rats as well as in conscious rats exposed to an ambient temperature of 22 degrees C. The central nature of this effect is confirmed by the antagonism exerted by haloperidol and the lack of antagonism with domperidone. Dopamine receptors involved in the hypothermic effect of apomorphine seem to be located in the preopticus medialis nucleus (p.o.m.n.) of the hypothalamus since: (i) injections of apomorphine (5 ng), dopamine (100 ng) or (+)-amphetamine (50 ng) into this nucleus induce hpothermia, (ii) haloperidol injected into the p.o.m.n. antagonizes the hypothermic effect of a systemic administration of apomorphine, (iii) heat lesions of the p.o.m.n. strongly reduce the hypothermic effect of a systemic injection of apomorphine.

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Citations

Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·R InabaT Moroji
Jan 1, 1990·Journal of Neural Transmission. General Section·B NaudinJ Costentin
Jan 1, 1993·Journal of Neural Transmission. General Section·S O OgrenM Widman
Jan 1, 1992·Psychopharmacology·M R Zarrindast, S A Tabatabai
Jan 28, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Chris W StoddartNadezda Urosevi
Jan 20, 1987·European Journal of Pharmacology·J E Faunt, A D Crocker
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Dec 1, 1991·Brain Research Bulletin·R M Quock, L K Vaughn
Jun 1, 1996·Journal of Ethnopharmacology·P N'gouemoC Nguemby-Bina
Mar 1, 1988·Alcohol·L P GonzalezJ F Czachura
Jul 1, 1997·Neuropharmacology·I DrouetJ Costentin
Dec 24, 1997·Neuroscience Letters·P Salmi, S Ahlenius
May 16, 2003·Pharmacology & Toxicology·Alexis Baker, Theo Meert
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Aug 22, 2009·Annales pharmaceutiques françaises·J Costentin
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·J S YunS K Oh

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