PMID: 2105819Jan 1, 1990Paper

Evidence for thyrotropin-releasing hormone and glucocorticoid receptor-immunoreactive neurons in various preoptic and hypothalamic nuclei of the male rat

Brain Research
A CintraJ A Gustafsson

Abstract

Neurons containing thyrotropin-releasing hormone (TRH) and glucocorticoid receptor (GR) immunoreactivity (IR) were demonstrated by a two-colour immunoperoxidase method in coronal cryotome sections of the preoptic region and the hypothalamus of the male rat brain. All the TRH-IR neurons (TRH-IR) located in the dorsal hypothalamus - medial and dorsal parvocellular parts of the paraventricular hypothalamic nucleus and the dorsomedial hypothalamic nucleus - and in the anterior periventricular hypothalamic nucleus were strongly GR-IR. The TRH-IR neurons of the medial preoptic area, the perifornical nucleus and the medial tuberal area were mostly weakly GR-IR and some lacked GR-IR. These data indicate a differential regulation of diencephalic TRH-IR neurons by glucocorticoids. They also imply that the inhibitory effect of glucocorticoids on TSH secretion may involve a direct inhibition of TRH synthesis and/or release by a nuclear action in the TRH-IR nerve cells of the paraventricular hypothalamic nucleus projecting to the median eminence.

References

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Citations

May 1, 1993·Molecular and Cellular Endocrinology·J KononenM Pelto-Huikko
Dec 1, 1991·Journal of Neuroendocrinology·D M Hayden-Hixson, C F Ferris
Sep 1, 1994·Anatomia, histologia, embryologia·R SarriaF Doñate Oliver
Sep 1, 1995·Clinical Endocrinology·C InvittiF Cavagnini
Nov 28, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Bryan R Haugen
Jul 15, 2015·Journal of Chemical Neuroanatomy·Chinatsu MoriwakiYoshihisa Fujikura
Jan 8, 2015·The Journal of Endocrinology·Patricia Joseph-BravoJean-Louis Charli
Apr 12, 2013·Endocrine Reviews·Ferdinand Roelfsema, Johannes D Veldhuis
Nov 26, 2020·The Journal of Clinical Endocrinology and Metabolism·Skand ShekharLynnette K Nieman
Jan 12, 2021·Endocrinology·Wenjie ChenJianyong Lei
Feb 10, 2021·Journal of Endocrinological Investigation·L CroceL Chiovato
Feb 6, 2021·Endocrinology·Wenjie ChenJianyong Lei
Apr 4, 2021·International Journal of Molecular Sciences·Rosa Maria ParagliolaSalvatore Maria Corsello
Apr 13, 2021·Stress : the International Journal on the Biology of Stress·Chad D ForadoriRobert J Kemppainen

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