PMID: 9188636Jul 1, 1997Paper

Evidence for translation of the Borna disease virus G protein by leaky ribosomal scanning and ribosomal reinitiation

Journal of Virology
P A SchneiderW I Lipkin

Abstract

The Borna disease virus antigenome includes five major open reading frames (ORFs) which encode, from 5' to 3', the putative nucleoprotein (N), the phosphoprotein (P), the putative matrix protein (M), the major glycoprotein (G), and the RNA-dependent RNA polymerase (pol). Whereas the N and P ORFs are translated from monocistronic transcripts, the M, G, and pol ORFs are translated from polycistronic transcripts. Expression of the M, G, and pol ORFs is dependent upon differential splicing of two introns (intron 1, 94 nucleotides [nt]; intron 2, 1,294 nt). In vitro transcription-translation assays of wild-type and mutant sequences indicated that the G ORF is translated from an unspliced 2.8-kb RNA by leaky ribosomal scanning. Splicing of intron 1 enhances the translation of the G ORF by converting the M ORF into a 13-amino-acid minicistron, a structure that facilitates ribosomal reinitiation.

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T BrieseW I Lipkin
Feb 1, 1992·The Journal of General Virology·J ThiererH Niemann
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W I LipkinM C Wilson
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Mar 1, 1994·Journal of Virology·B CubittJ C de la Torre
Nov 1, 1994·Journal of Virology·S KlicheW I Lipkin
Aug 1, 1994·Journal of Virology·P A SchneiderW I Lipkin
Jan 1, 1994·Virus Research·K I Kamrud, C S Schmaljohn
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·T BrieseW I Lipkin
Jan 1, 1994·Journal of Virology·P A SchneiderW I Lipkin
Jan 1, 1997·Journal of Virology·P A SchneiderW I Lipkin

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Citations

Feb 20, 2008·Neuropathology and Applied Neurobiology·N Werner-KeissC Herden
Sep 12, 2006·Nature Reviews. Microbiology·Juan C de la Torre
Nov 9, 2002·The Journal of Infectious Diseases·Juan Carlos de la Torre
Feb 15, 2001·The Journal of General Virology·B CubittJ C de la Torre
May 16, 1998·The Journal of Biological Chemistry·M SchwemmleW I Lipkin
Oct 9, 2020·Virus Evolution·Paul DigardEleanor Gaunt
Mar 10, 2001·Reviews in Medical Virology·I Jordan, W I Lipkin
Sep 2, 2009·Virus Research·Ulrike SiemetzkiW Ian Lipkin

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