Evidence for treating peripheral arterial diseases with biodegradable scaffolds

The Journal of Cardiovascular Surgery
Tsz M ChuStephen W Cheng

Abstract

The new technology of biodegradable scaffolds has the advantage of "leaving nothing behind", whilst allowing the vessel to restore to normal wall integrity. This new approach attempts to circumvent the chronic local inflammatory reaction due to permanent implantation of a foreign body. The aim of this paper was to examine the published literature on the use of biodegradable stents in the treatment of peripheral arterial diseases (PAD). Systematic review was formulated under the instruction of PRIMSA guideline. Papers published from January 2005 to March 2015 in English language were included. Published studies on biodegradable scaffolds or stents in the treatment of PAD were systematically searched and reviewed through a computerized search of Pubmed and Ovid MEDLINE and cross-referenced. Key words include "biodegradable scaffolds", "biodegradable stents", "femoral", "lower limb", "peripheral arterial disease" and "peripheral vascular disease". All relevant published papers which fulfilled these criteria were reviewed. On-going studies from other electronic databases were also examined. A total of 75 non-duplicated publications were identified, but only 6 articles were eligible into our qualitative analysis (one animal study, 3...Continue Reading

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