Evidence for two different modes of tripeptide disappearance in human intestine. Uptake by peptide carrier systems and hydrolysis by peptide hydrolases

The Journal of Clinical Investigation
S A AdibiP M Amin

Abstract

The intestinal fate of two tripeptides (triglycine and trileucine), which differ markedly in solubility and molecular weight, have been investigated by jejunal perfusion in healthy human volunteers. Rates of glycine or leucine uptake from test solutions containing triglycine or trileucine were greater than from test solutions containing corresponding amounts of free glycine or free leucine, respectively. The rate of glycine uptake from a 100 mM triglycine solution was greater than that from a 150 mM diglycine solution. At each infused load of triglycine (e.g., 1,000 mumol/min) the rates (micromoles/minutes per 30 cm) of either triglycine disappearance (810 +/- 40) or glycine absorption (2,208 +/- 122) were markedly greater than the luminal accumulation rates of either diglycine (56 +/- 10) or free glycine (110 +/- 18). The luminal accumulation rate of free leucine during infusion of a 5 mM trileucine solution was over threefold greater than that of free glycine during the infusion of a 5 mM triglycine solution. Luminal fluid exhibited no hydrolytic activity against triglycine, but contained some activity against trileucine. Saturation of free amino acid carrier system with a large load of leucine did not affect glycine absorpti...Continue Reading

References

Dec 1, 1972·Gut·M D HellierD Perrett
May 1, 1974·The Journal of Clinical Investigation·S A Adibi, M R Soleimanpour
Sep 1, 1966·The Journal of Clinical Investigation·B FleshlerJ D Wismar
Feb 1, 1968·The Journal of Clinical Investigation·H P SchedlJ A Clifton
Jan 1, 1963·The Journal of Clinical Investigation·E MEILMANC M RAPOPORT

❮ Previous
Next ❯

Citations

Nov 17, 1989·Biochimica Et Biophysica Acta·D WilsonK Ramaswamy
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·I Tarvid
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·Toshiro MatsuiTerukazu Kawasaki
Mar 22, 1979·The New England Journal of Medicine·M H Sleisenger, Y S Kim
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J MårtenssonA Meister
Aug 1, 1978·Gut·L J MillerV L Go
Feb 24, 2004·Annual Review of Physiology·Hannelore Daniel
Aug 20, 2010·Journal of Nutrition and Metabolism·E De GreefG Veereman-Wauters
Sep 1, 1977·The Journal of Clinical Investigation·K W Smithson, G M Gray
Nov 1, 1977·The Journal of Clinical Investigation·S A Adibi, E L Morse
Jan 31, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Michael D RobertsFrank W Booth
Jan 28, 2015·Nutrition Research Reviews·Warren M Miner-WilliamsPaul J Moughan
Feb 1, 1980·The Proceedings of the Nutrition Society·D B Silk
Oct 1, 1987·Metabolism: Clinical and Experimental·S A Adibi
May 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·A Davis, S Baker
May 8, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Hugh James Freeman
Jul 1, 1996·Journal of Peptide Science : an Official Publication of the European Peptide Society·G Fricker, J Drewe
Aug 9, 2019·Molecular Nutrition & Food Research·Florian RohmBritta Spanier
Feb 1, 1985·The Proceedings of the Nutrition Society·D B SilkR G Rees
Apr 1, 1977·Australian and New Zealand Journal of Medicine·S Whittingham, I R Mackay
Oct 17, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Siamak A Adibi
Jan 1, 1982·Die Nahrung·M Friedrich
Dec 17, 2003·Journal of Pediatric Gastroenterology and Nutrition·Jon A Vanderhoof, Rosemary J Young
May 1, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mingmin ChenUrsula Seidler
Nov 1, 1976·Metabolism: Clinical and Experimental·S A Adibi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.