Evidence for two distinct chloride uniport pathways in brown adipose tissue mitochondria.

The American Journal of Physiology
P JezekK D Garlid

Abstract

Chloride permeability of the inner membrane of brown adipose tissue mitochondria was analyzed by monitoring mitochondrial swelling in KCl salts in the presence of K+ ionophores. The results indicate that the high anion conductance observed in these mitochondria is due to the presence of two separate pathways: 1) a Cl-conducting pathway that is inhibited by guanosine 5'-diphosphate (GDP) but neither by N,N'-dicyclohexylcarbodiimide (DCCD) nor by amphiphilic amines and that is found uniquely in brown adipose tissue mitochondria and 2) an inner membrane anion uniport channel that is inhibited both by DCCD and by amphiphilic amines but not by GDP and that is opened either by depletion of matrix Mg2+ or by alkalinization of the matrix.

References

Jan 15, 1976·Biochimica Et Biophysica Acta·G F AzzoneT Pozzan
Feb 1, 1979·Biochemical Society Transactions·M J SelwynD V Fulton
Jan 1, 1986·Biochimica Et Biophysica Acta·K D Garlid, A D Beavis
Dec 3, 1987·Nature·M J Selwyn
Sep 3, 1973·European Journal of Biochemistry·D G Nicholls, O Lindberg
Jul 3, 1967·Biochimica Et Biophysica Acta·A Azzi, G F Azzone
Jun 1, 1984·Biochemical Society Transactions·D G NichollsE Rial

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Citations

Dec 15, 1993·European Journal of Biochemistry·D Ricquier, A M Cassard-Doulcier
Apr 3, 2014·Physiological Reviews·Ildiko Szabo, Mario Zoratti
Feb 1, 1992·Journal of Bioenergetics and Biomembranes·A D Beavis
Apr 3, 2021·Biochimica Et Biophysica Acta. Bioenergetics·David G Nicholls
Jun 1, 1996·The International Journal of Biochemistry & Cell Biology·P Jezek, J Borecký
Mar 29, 1994·Biochimica Et Biophysica Acta·R Krämer
Feb 12, 2004·Biochimica Et Biophysica Acta·Eduardo RialAmalia Ledesma

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