Evidence for white matter abnormalities in schizophrenia.

Current Opinion in Psychiatry
Marek KubickiMartha E Shenton

Abstract

The purpose of this review is to highlight important recent imaging, histological, and genetic findings relevant to white matter abnormalities in schizophrenia. It is cast within the context of research findings conducted over the last 5 years, where we analyze their importance in understanding schizophrenia, as well as discuss future directions for research. White matter abnormalities have long been hypothesized in schizophrenia, although only recently has it become possible to investigate them more closely. This has come about as a result of advances in neuroimaging, including new imaging techniques sensitive to white matter structure, as well as advances in computer science, with new analysis techniques making it possible to evaluate several interconnected brain regions at a time. Postmortem studies, with advances such as fluoroscopy and electron microscopy, have also led to quantifying populations of different brain cells, including myelin-forming oligodendrocytes. Moreover, molecular studies enable examination of immunoreactivity of proteins that are responsible for building myelin sheaths. Additionally, microarray genetic studies allow us to investigate myelin-related genes in schizophrenia. Taken together, these technolo...Continue Reading

References

Mar 22, 1990·The New England Journal of Medicine·R L SuddathD R Weinberger
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Aug 26, 1995·Lancet·D R Weinberger
Apr 1, 1995·Archives of General Psychiatry·C G WibleR W McCarley
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Jul 1, 1996·Psychological Medicine·P K McGuire, C D Frith
Apr 10, 1999·Archives of General Psychiatry·K O LimA Pfefferbaum
Dec 22, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·J FoongM A Ron
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HakakA A Fienberg
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Sep 29, 2001·Brain Research Bulletin·D R CotterI P Everall
Sep 29, 2001·Brain Research Bulletin·N UranovaV Rachmanova
May 3, 2002·The American Journal of Psychiatry·Marek KubickiMartha E Shenton
Dec 19, 2002·NMR in Biomedicine·K O Lim, J A Helpern
Dec 31, 2002·The American Journal of Psychiatry·Beng-Choon HoNancy C Andreasen
Mar 8, 2003·Archives of General Psychiatry·Daniel H MathalonEdith V Sullivan
May 2, 2003·The British Journal of Psychiatry : the Journal of Mental Science·J BurnsS M Lawrie
May 14, 2003·Archives of General Psychiatry·Kenneth L DavisVahram Haroutunian
Sep 19, 2003·Lancet·Dmitri TkachevSabine Bahn

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Citations

Apr 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·Thomas ZetzscheEva M Meisenzahl
Jan 1, 2011·Brain Connectivity·Sarah A J ReadingChristopher A Ross
Sep 15, 2010·Brain : a Journal of Neurology·Astrid C van der SchotRené S Kahn
Oct 10, 2008·Cerebral Cortex·Paul M ThompsonUNKNOWN HGDH Study Group
Jul 10, 2012·Cerebral Cortex·Aristotle N VoineskosJames L Kennedy
Nov 21, 2013·Brain : a Journal of Neurology·Tiago Reis MarquesPaola Dazzan
Jun 3, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Mark WalterfangChristos Pantelis
Oct 15, 2008·The International Journal of Neuroscience·Subroto GhoseMayada Akil
Jul 11, 2009·Expert Review of Neurotherapeutics·Hans-Gert BernsteinBernhard Bogerts
Jun 21, 2014·Schizophrenia Research·Hans-Gert BernsteinBernhard Bogerts
Aug 23, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alan N FrancisMatcheri S Keshavan
Jun 12, 2010·Psychiatry Research·Nikolaos MakrisJill M Goldstein
May 18, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martijn P van den Heuvel, Hilleke E Hulshoff Pol
Feb 24, 2010·Bio Systems·Bernhard J Mitterauer
Dec 1, 2009·The Psychiatric Clinics of North America·Arman Danielyan, Henry A Nasrallah
Aug 5, 2008·Neurochemistry International·Bjørnar HasselAndreas Lossius
Aug 19, 2007·Biological Psychology·Cosima FrankeNorbert Kathmann
Oct 18, 2007·Journal of Neuroscience Research·Serafina SalvatiLuigi Vitelli
Aug 7, 2008·Journal of Neuroscience Research·Sujatha NarayanElizabeth A Thomas
Sep 29, 2011·CNS Neuroscience & Therapeutics·Bernhard J Mitterauer
Nov 14, 2006·Schizophrenia Research·Adegboyega SaparaVeena Kumari
Jul 21, 2006·Schizophrenia Research·Serge A MitelmanMonte S Buchsbaum
Nov 3, 2010·Biological Psychiatry·Andrew ZaleskyChristos Pantelis
Mar 12, 2015·Psychiatry and Clinical Neurosciences·Chenyao WangNorio Ozaki
Nov 8, 2014·NeuroImage. Clinical·Maria de la Iglesia-VayaJulio Sanjuan
Jun 28, 2011·Medical Hypotheses·Rami Bou Khalil
Aug 13, 2011·Schizophrenia Research·Fabiana da Silva AlvesTherese van Amelsvoort
Apr 24, 2015·Molecular Neurobiology·Enrico CocchiAlessandro Serretti
Jan 30, 2007·Neuropsychologia·Benedikt ReuterNorbert Kathmann
Jan 27, 2015·Schizophrenia Research·Patricia Alvarado-AlanisCamilo de la Fuente-Sandoval
Feb 5, 2015·Psychiatry Research·Gianfranco SpallettaChiara Chiapponi

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