Evidence from animal models on the pathogenesis of PCOS

Best Practice & Research. Clinical Endocrinology & Metabolism
Kirsty A WaltersDavid J Handelsman

Abstract

Polycystic ovarian syndrome (PCOS) is the most common endocrine condition in women, and is characterized by reproductive, endocrine and metabolic features. However, there is no simple unequivocal diagnostic test for PCOS, its etiology remains unknown and there is no cure. Hence, the management of PCOS is suboptimal as it relies on the ad hoc empirical management of its symptoms only. Decisive studies are required to unravel the origins of PCOS, but due to ethical and logistical reasons these are not possible in humans. Experimental animal models for PCOS have been established which have enhanced our understanding of the mechanisms underlying PCOS and propose novel mechanism-based therapies to treat the condition. This review examines the findings from various animal models to reveal the current knowledge of the mechanisms underpinning the development of PCOS, and also provides insights into the implications from these studies for improved clinical management of this disorder.

Citations

Oct 31, 2018·Endocrinology·Joabel Tonellotto Dos SantosFabio Vasconcellos Comim
Apr 3, 2019·The Journal of Clinical Endocrinology and Metabolism·Nigel K SteptoRaymond J Rodgers
Jul 3, 2019·Endocrinology·Amy Ruddenklau, Rebecca E Campbell
Dec 31, 2019·International Journal of Endocrinology·Xiaoshuai ZhangZhiwen Lai
May 2, 2019·Reproduction, Fertility, and Development·Silvana R FerreiraAlicia B Motta
Aug 31, 2019·Medical Sciences : Open Access Journal·Valentina Rodriguez Paris, Michael J Bertoldo
Oct 18, 2020·Nature Communications·Valentina Rodriguez ParisKirsty A Walters
Jan 25, 2020·International Journal of Biological Macromolecules·Shun ZhangXiaocan Lei
Jun 1, 2021·Journal of the Endocrine Society·Valentina Rodriguez ParisKirsty A Walters
Aug 24, 2021·International Journal of Endocrinology·Na LiYuanpeng Liao

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