Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behaviour caused by immune challenge.

Journal of Psychopharmacology
E PainsippP Holzer

Abstract

Neuropeptide Y participates in the acute behavioural responses to immune challenge, since Y2 receptor knockout (Y2⁻/⁻) mice are particularly sensitive to the short-term anxiogenic-like effect of bacterial lipopolysaccharide. The present exploratory study addressed the involvement of Y2 and Y4 receptors in the long-term behavioural responses to immune challenge. A single intraperitoneal injection of lipopolysaccharide (0.83 mg/kg) to control mice did not affect open field behaviour 3 h post-treatment but enhanced anxiety-like behaviour in Y2⁻/⁻ as well as Y4⁻/⁻ mice. Four weeks post-treatment this behavioural effect of lipopolysaccharide persisted in Y4⁻/⁻ mice but had gone in Y2⁻/⁻ mice. Depression-related behaviour in the forced swim test was enhanced 1 day post-lipopolysaccharide in control and Y2⁻/⁻ mice, but not in Y4⁻/⁻ mice. Four weeks post-treatment, the depressogenic-like effect of lipopolysaccharide had waned in control mice, persisted in Y2⁻/⁻ mice and was first observed in Y4⁻/⁻ mice. In summary, knockout of Y2 and/or Y4 receptors unmasks the ability of a single lipopolysaccharide injection to cause a delayed and prolonged increase in anxiety- and/or depression-like behaviour. These findings suggest that neuropeptide...Continue Reading

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Citations

Sep 3, 2013·British Journal of Pharmacology·Evelin PainsippPeter Holzer
Aug 16, 2014·Psychoneuroendocrinology·Mustafa al'AbsiMotohiro Nakajima
Dec 8, 2017·Frontiers in Immunology·Peter HolzerFlorian Reichmann
Jul 29, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Tongyuan HuMing D Li
Sep 9, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Chunrong LiKangding Liu
Aug 22, 2017·Frontiers in Endocrinology·Annika Thorsell, Aleksander A Mathé
Jul 25, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Geraldine ZenzPeter Holzer
Sep 5, 2019·Frontiers in Neuroscience·Chunrong LiKangding Liu
Jan 8, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Felipe Dal-PizzolTarek Sharshar

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