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Evidence from rats that morphine tolerance is a learned response

Journal of Comparative and Physiological Psychology

Jul 1, 1975

Shepard Siegel

PMID: 425

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Abstract

It is proposed that the direct analgesic effect of morphine becomes attenuated over the course of successive administrations of the narcotic by a conditioned, compensatory, hyperalgesic response elicited by the administration procedure, the net result being analgesic tolerance. Using th...read more

Mentioned in this Paper

Morphine
Drug Tolerance
Placebos
Analgesia [PE]
Mental Association
Analgesics
Morphine Sulfate (2: 1), Pentahydrate
Reaction Time
Absence of Pain Sensation
Extinction, Psychological
Paper Details
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    • Citations243
  • Evidence from rats that morphine tolerance is a learned response

    Journal of Comparative and Physiological Psychology

    Jul 1, 1975

    Shepard Siegel

    PMID: 425

    DOI:

    Abstract

    It is proposed that the direct analgesic effect of morphine becomes attenuated over the course of successive administrations of the narcotic by a conditioned, compensatory, hyperalgesic response elicited by the administration procedure, the net result being analgesic tolerance. Using th...read more

    Mentioned in this Paper

    Morphine
    Drug Tolerance
    Placebos
    Analgesia [PE]
    Mental Association
    Paper Details
    References
    • References
    • Citations243

      References currently unavailable

      We're still populating references for this paper, please check back later.
    • References
    • Citations243
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