PMID: 6980416Jun 1, 1982Paper

Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis

Proceedings of the National Academy of Sciences of the United States of America
L KlareskogH Wigzell

Abstract

Originating from observations on similarities between the rheumatoid synovial tissue and skin lesions in delayed-type hypersensitivity reactions--similarities as to massive infiltrates of "helper" T lymphocytes close to HLA-DR-expressing macrophage/dendritic cells--a notion is formed on the importance of local macrophage-dependent helper T-cell activation in the rheumatoid joint similar to that in a delayed-type skin reaction. In vitro studies on suspended synovial cells have been used to test and qualify these ideas. It is shown that (i) HLA-DR-expressing cells in normal synovial intima can, like epidermal Langerhans cells, mediate T-cell activation; (ii) the large numbers of rheumatoid synovial HLA-DR-expressing macrophage-like/dendritic cells are heterogeneous and mediate either efficient activation or suppression of T-lymphocyte proliferation, and (iii) specificity of rheumatoid T cells can be analyzed with the help of autologous synovial antigen-presenting cells; a specific anti-collagen type II response is reported in three patients.

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Citations

Aug 1, 1996·Arthritis and Rheumatism·C Hernández-GarcíaJ A Jover
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Apr 5, 2008·Current Opinion in Rheumatology·Lars KlareskogJohan Rönnelid
Sep 1, 1995·Journal of Internal Medicine·L KlareskogG Holm

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