PMID: 2111173May 1, 1990Paper

Evidence in vitro that hepatic lipase reduces the concentration of apolipoprotein A-I in rabbit high-density lipoproteins

Biochimica Et Biophysica Acta
M A ClayP J Barter

Abstract

Incubation of rabbit plasma in vitro with hepatic lipase resulted in the hydrolysis of triacylglycerol in high-density lipoproteins (HDL) and a reduction in HDL particle size. These changes were accompanied by a decrease in the concentration of apolipoprotein A-I (apo A-I) in the HDL. The loss of apo A-I was demonstrated independently by ultracentrifugation, size exclusion chromatography and gradient gel-immunoblot analysis. It was unrelated to hydrolysis of HDL phospholipids but did correlate with the reduction in HDL particle size. These studies suggest that the concentration of apo A-I in HDL may be influenced by factors which regulate the metabolism of HDL core lipid constituents.

References

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Citations

Sep 17, 1999·Atherosclerosis·K A RyeP J Barter
Sep 1, 1994·Clinical and Experimental Pharmacology & Physiology·P Barter, K A Rye
Aug 15, 2006·Journal of the American College of Cardiology·Stephen J NichollsDavid S Celermajer
Nov 28, 2002·Journal of Lipid Research·Karin Conde-KnapeNeil S Shachter
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M A ClayP J Barter
Dec 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S A SchreyerA D Attie
Sep 6, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephen J NichollsPhilip J Barter
Dec 7, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jonathan G BoucherDaniel L Sparks
Jun 27, 1995·Biochimica Et Biophysica Acta·H Q LiangP J Barter

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