DOI: 10.1101/19012088Nov 15, 2019Paper

Evidence linking atopy and staphylococcal superantigens to the pathogenesis of lymphomatoid papulosis, a recurrent CD30+ cutaneous lymphoproliferative disorder

MedRxiv : the Preprint Server for Health Sciences
M E KadinE C Vonderheid

Abstract

Background: Lymphomatoid papulosis (LyP) is a self-healing CD30+ cutaneous lymphoproliferative disorder (CLPD) with paradoxical histology of a malignant lymphoma. Case reports and small patient series suggest an association of LyP with atopy. However, the prevalence of atopy depends on patient recall which is not always reliable. More objective criteria of atopy include skin reactivity to allergens and IgE reactivity to allergens. This study was undertaken to determine if atopy is prevalent in LyP patients using IgE specific antibodies to aeroallergens, and if Staphylococcal aureus enterotoxins might be a pathogenic factors for LyP as proposed for other skin disorders. Methods: Thirty-one samples of patients with CD30+ CLPD were tested for total serum IgE (IgE-t) and 10 IgE-specific airborne allergens with the Phadiatop multiallergen test, which if positive, is regarded as evidence of atopy. Sera was tested for IgE reactive against three Staphylococcal enterotoxins with superantigenic properties (SSAg-IgE). Control sera were obtained from adult subjects evaluated for rhino-sinusitis and a negative Phadiatop test. Patient history of atopy was obtained by retrospective chart review. Findings: Nearly 50% of LyP patients had a posi...Continue Reading

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