PMID: 7539412May 29, 1995Paper

Evidence of a chromatin basis for increased mutagen sensitivity associated with multiple primary malignancies of the head and neck

International Journal of Cancer. Journal International Du Cancer
Tej K Pandita, W N Hittelman

Abstract

Individuals at increased risk for cancer development have been reported to exhibit increased mutagen sensitivity as detected by the G2 phase chromosome breakage assay. To better understand the basis for such chromosome sensitivity, we examined 4 lymphoblastoid cell lines derived from 4 head and neck cancer patients, 2 of whom were previously shown to have normal bleomycin sensitivity and 2 high bleomycin sensitivity (and multiple primary tumors). These cell lines were studied for cell survival and initial damage and repair at both the DNA and chromosome levels, and the results compared to a normal control cell line and 3 ataxia telangiectasia homozygote cell lines. While all cell lines exhibited nearly equal levels of initial DNA damage and repair throughout the cell cycle, both the ataxia telangiectasia homozygote cell lines and 2 cell lines derived from individuals with multiple head and neck primary tumors showed increased levels of initial chromosome damage (detected by premature chromosome condensation), a reduced fast repair component and higher residual chromosome damage. Our results suggest that one component of the enhanced mutagen sensitivity phenotype observed in cancer-prone individuals may involve an inherent chrom...Continue Reading

References

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Citations

Sep 27, 1996·International Journal of Cancer. Journal International Du Cancer·J CloosB J Braakhuis
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·R K PatelD D Patel
Feb 13, 2001·Critical Reviews in Oncology/hematology·R Parshad, K K Sanford
Feb 5, 1997·Journal of the National Cancer Institute·F R KhuriW K Hong
Oct 18, 2001·Journal of the National Cancer Institute·M L BondyQ Wei
Jun 1, 2005·Molecular and Cellular Biology·Arun GuptaTej K Pandita
May 7, 1999·Environmental Health Perspectives·R E ShackelfordR S Paules
Nov 4, 2009·Critical Reviews in Eukaryotic Gene Expression·Tej K PanditaSukesh R Bhaumik
Sep 25, 2008·Journal of Medical Case Reports·Jen-Hsun ChengChong-Bin Tsai
Nov 11, 1999·Oncogene·G Rotman, Y Shiloh
Oct 18, 2001·Radiation Research·T K Pandita
Mar 4, 1999·The Journal of Nutrition·C Lai, P G Shields
Jul 17, 1998·Experimental Cell Research·M L SmithA J Fornace

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