PMID: 8588701Jun 1, 1995Paper

Evidence of a direct role for growth hormone (GH) in mammary gland proliferation and lactation

Anatomia, histologia, embryologia
D T LincolnM J Waters

Abstract

A panel of monoclonal antibodies to the growth hormone (GH) receptor/binding protein was used to demonstrate the existence and detail the expression of GH receptors in ductal and alveolar epithelial cells from rat and rabbit mammary glands by immunohistochemistry. Intense immunoreactivity was present in membrane, cytoplasm and some nuclei of epithelial cells during proliferation and lactation. Receptor expression decreased during weaning and was absent or weak in regressive mammary glands. Immunoreactivity was weak in ductal epithelial cells from virgin adult animals. Pronounced expression of GH receptor/binding protein was observed with two monoclonal antibodies and lesser reactivity was seen with others, paralleling their affinities for the receptor. The cytoplasmic presence of this putatively plasma membrane located GH receptor is accounted for by the existence of a soluble form on the GH receptor, namely the growth hormone binding protein derived from the membrane receptor by cleavage. Primary localization of the receptor in proliferating and lactating epithelial cells suggests that the rat and rabbit mammary gland is a GH target tissue. This finding is in contradiction to both classical GH action and the somatomedin hypoth...Continue Reading

References

Sep 1, 1990·The Journal of Endocrinology·D R GlimmJ J Kennelly
Apr 1, 1985·The Journal of Clinical Endocrinology and Metabolism·W Kiess, O Butenandt
Sep 1, 1987·Journal of Dairy Science·G B Silberstein, C W Daniel
Aug 1, 1982·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A C Herington
Dec 1, 1983·The Journal of Clinical Endocrinology and Metabolism·L J MurphyL Lazarus
Oct 1, 1980·Physiological Reviews·Y J Topper, C S Freeman
Dec 17, 1958·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·W R LYONS

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Citations

Sep 15, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G L Matejka, B A Bengtsson
Apr 21, 1998·Toxicologic Pathology·C A Bondy
Mar 6, 2004·Journal of Animal Science·A V CapucoM J Paape

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