Nov 8, 2018

Evidence of a noncoding transcript of the RIPK2 gene overexpressed in head and neck tumor

BioRxiv : the Preprint Server for Biology
Eloiza Helena TajaraPatricia Severino


Receptor-interacting proteins are a family of serine/threonine kinases, which integrate extra and intracellular stress signals caused by different factors, including infections, inflammation and DNA damage. Receptor-interacting serine/threonine-protein kinase 2 (RIP-2) is a member of this family and an important component of the nuclear factor NF-kappa-B signaling pathway. The corresponding human gene RIPK2 generates two transcripts by alternative splicing, the full-length and a short transcript. The short transcript has a truncated 5’ sequence, which results in a predicted isoform with a partial kinase domain but able to transduce signals through its caspase recruitment domain. In this study, the expression of RIPK2 was investigated in human tissue samples and, in order to determine if both transcripts are similarly regulated at the transcriptional level, cancer cell lines were submitted to temperature and acid stresses. We observed that both transcripts are expressed in all tissues analyzed, with higher expression of the short one in tumor samples, and they are differentially regulated following temperature stress. Despite transcription, no corresponding protein for the short transcript was detected in tissues and cell lines ...Continue Reading

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Mentioned in this Paper

Receptor-Interacting Protein Serine-Threonine Kinases
RNA, Untranslated
Transcription, Genetic
Signal Transduction Pathways
NFKB1 wt Allele
Total Tissue
Neck Neoplasms

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